Anaplastic large cell lymphoma presenting as a cerebellar mass
Anaplastic large cell lymphoma (ALCL) is a T cell lymphoma occurring commonly in childhood and rarely in adults. Central nervous system involvement in ALCL is very rare and cerebellar involvement at presentation has never been described. We examine the case of a young adult who presented with a cere...
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doaj-a1dc94bc5fc9402ea15890c8f34b00fc2020-11-24T21:11:52ZengElsevierHematology/Oncology and Stem Cell Therapy1658-38762014-12-0174157161Anaplastic large cell lymphoma presenting as a cerebellar massN. Geetha0K.P. Sreelesh1Rekha Nair2Anitha Mathews3Department of Medical Oncology, Regional Cancer Centre, Trivandrum 695011, Kerala, India; Corresponding author. Tel.: +91 9447500920.Department of Medical Oncology, Regional Cancer Centre, Trivandrum 695011, Kerala, IndiaDepartment of Pathology, Regional Cancer Centre, Trivandrum 695011, IndiaDepartment of Pathology, Regional Cancer Centre, Trivandrum 695011, IndiaAnaplastic large cell lymphoma (ALCL) is a T cell lymphoma occurring commonly in childhood and rarely in adults. Central nervous system involvement in ALCL is very rare and cerebellar involvement at presentation has never been described. We examine the case of a young adult who presented with a cerebellar mass.A 19-year-old boy presented with signs of raised intracranial tension, which, on imaging, revealed a right cerebellar mass. He underwent suboccipital craniotomy and partial excision of the tumor. However, the histopathology was inconclusive. He subsequently presented with cerebellar signs and repeat imaging showed recurrence of the cerebellar lesion. He underwent decompression and ventriculoperitoneal (VP) shunting. Histopathology was suggestive of ALK (anaplastic lymphoma kinase) positive anaplastic large cell lymphoma. The patient was started on chemotherapy. However, his neurological status deteriorated, his condition worsened, and he expired a month later. Keywords: ALCL, Cerebellum, Brain, NHLhttp://www.sciencedirect.com/science/article/pii/S1658387614000521 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
N. Geetha K.P. Sreelesh Rekha Nair Anitha Mathews |
spellingShingle |
N. Geetha K.P. Sreelesh Rekha Nair Anitha Mathews Anaplastic large cell lymphoma presenting as a cerebellar mass Hematology/Oncology and Stem Cell Therapy |
author_facet |
N. Geetha K.P. Sreelesh Rekha Nair Anitha Mathews |
author_sort |
N. Geetha |
title |
Anaplastic large cell lymphoma presenting as a cerebellar mass |
title_short |
Anaplastic large cell lymphoma presenting as a cerebellar mass |
title_full |
Anaplastic large cell lymphoma presenting as a cerebellar mass |
title_fullStr |
Anaplastic large cell lymphoma presenting as a cerebellar mass |
title_full_unstemmed |
Anaplastic large cell lymphoma presenting as a cerebellar mass |
title_sort |
anaplastic large cell lymphoma presenting as a cerebellar mass |
publisher |
Elsevier |
series |
Hematology/Oncology and Stem Cell Therapy |
issn |
1658-3876 |
publishDate |
2014-12-01 |
description |
Anaplastic large cell lymphoma (ALCL) is a T cell lymphoma occurring commonly in childhood and rarely in adults. Central nervous system involvement in ALCL is very rare and cerebellar involvement at presentation has never been described. We examine the case of a young adult who presented with a cerebellar mass.A 19-year-old boy presented with signs of raised intracranial tension, which, on imaging, revealed a right cerebellar mass. He underwent suboccipital craniotomy and partial excision of the tumor. However, the histopathology was inconclusive. He subsequently presented with cerebellar signs and repeat imaging showed recurrence of the cerebellar lesion. He underwent decompression and ventriculoperitoneal (VP) shunting. Histopathology was suggestive of ALK (anaplastic lymphoma kinase) positive anaplastic large cell lymphoma. The patient was started on chemotherapy. However, his neurological status deteriorated, his condition worsened, and he expired a month later. Keywords: ALCL, Cerebellum, Brain, NHL |
url |
http://www.sciencedirect.com/science/article/pii/S1658387614000521 |
work_keys_str_mv |
AT ngeetha anaplasticlargecelllymphomapresentingasacerebellarmass AT kpsreelesh anaplasticlargecelllymphomapresentingasacerebellarmass AT rekhanair anaplasticlargecelllymphomapresentingasacerebellarmass AT anithamathews anaplasticlargecelllymphomapresentingasacerebellarmass |
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1716752418925969408 |