Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans[S]

Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans[S]

Elevated nonfasting TG-rich lipoprotein levels are a risk factor for CVD. To further evaluate the relevance of LDL-receptor (LDLr) pathway and heparan sulfate proteoglycans (HSPGs) in TG homeostasis, we analyzed fasting and postprandial TG levels in mice bearing combined heterozygous mutations in bo...

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Bibliographic Details
Main Authors: Hans L. Mooij, Sophie J. Bernelot Moens, PhilipL.S.M. Gordts, KristinI. Stanford, ErinM. Foley, MarjoleinA.W. van den Boogert, JuliaJ. Witjes, H.Carlijne Hassing, MichaelW. Tanck, MichielA.J. van de Sande, J.Han Levels, JohnJ.P. Kastelein, ErikS.G. Stroes, GeesjeM. Dallinga-Thie, JeffD. Esko, Max Nieuwdorp
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Journal of Lipid Research
Subjects:
triglycerides
heparan sulfates
hereditary multiple exostoses
familial hypercholesterolemia
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520355942

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