Ventricular Repolarization is Associated with Cognitive Function, but Not with Cognitive Decline and Brain Magnetic Resonance Imaging (MRI) Measurements in Older Adults
We aimed to investigate the cross-sectional and longitudinal associations of electrocardiogram (ECG)-based QT, QTc, JT, JTc, and QRS intervals with cognitive function and brain magnetic resonance imaging (MRI) measurements in a cohort of older individuals at increased risk for cardiovascular disease...
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doaj-a1ec858130184d8aa24abab222e44a6e2020-11-25T02:39:34ZengMDPI AGJournal of Clinical Medicine2077-03832020-03-019491110.3390/jcm9040911jcm9040911Ventricular Repolarization is Associated with Cognitive Function, but Not with Cognitive Decline and Brain Magnetic Resonance Imaging (MRI) Measurements in Older AdultsMichelle H. Zonneveld0Raymond Noordam1Jeroen van der Grond2Behnam Sabayan3Simon P. Mooijaart4Peter W. Mcfarlane5J. Wouter Jukema6Stella Trompet7Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, 2333 ZA Leiden, the NetherlandsDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, 2333 ZA Leiden, the NetherlandsDepartment of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The NetherlandsNorthwestern University, Feinberg School of Medicine, Chicago, IL 60611, USADepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, 2333 ZA Leiden, the NetherlandsInstitute of Health and Wellbeing, University of Glasgow, Glasgow G31 2ER, UKDepartment of Cardiology, Leiden University Medical Center, 2333 ZA Leiden, The NetherlandsDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, 2333 ZA Leiden, the NetherlandsWe aimed to investigate the cross-sectional and longitudinal associations of electrocardiogram (ECG)-based QT, QTc, JT, JTc, and QRS intervals with cognitive function and brain magnetic resonance imaging (MRI) measurements in a cohort of older individuals at increased risk for cardiovascular disease, but free of known arrhythmias. We studied 4627 participants (54% female, mean age 75 years) enrolled in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Ten-second ECGs were conducted at baseline. Cognitive function was tested at baseline and repeated during a mean follow-up time of 3.2 years. Structural MRIs were conducted in a subgroup of 535 participants. Analyses were performed with multivariable (repeated) linear regression models and adjusted for cardiovascular risk-factors, co-morbidities, and cardiovascular drug use. At baseline, longer QT, JT, JTc—but not QTc and QRS intervals—were associated with a worse cognitive performance. Most notably, on the Stroop Test, participants performed 3.02 (95% CI 0.31; 5.73) seconds worse per standard deviation higher QT interval, independent of cardiovascular risk factors and medication use. There was no association between longer ventricular de- or repolarization and structural brain measurements. Therefore, specifically ventricular repolarization was associated with worse cognitive performance in older individuals at baseline but not during follow-up.https://www.mdpi.com/2077-0383/9/4/911older adultscardiovascular diseasecognitive dysfunctionmriprolonged qt interval |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michelle H. Zonneveld Raymond Noordam Jeroen van der Grond Behnam Sabayan Simon P. Mooijaart Peter W. Mcfarlane J. Wouter Jukema Stella Trompet |
spellingShingle |
Michelle H. Zonneveld Raymond Noordam Jeroen van der Grond Behnam Sabayan Simon P. Mooijaart Peter W. Mcfarlane J. Wouter Jukema Stella Trompet Ventricular Repolarization is Associated with Cognitive Function, but Not with Cognitive Decline and Brain Magnetic Resonance Imaging (MRI) Measurements in Older Adults Journal of Clinical Medicine older adults cardiovascular disease cognitive dysfunction mri prolonged qt interval |
author_facet |
Michelle H. Zonneveld Raymond Noordam Jeroen van der Grond Behnam Sabayan Simon P. Mooijaart Peter W. Mcfarlane J. Wouter Jukema Stella Trompet |
author_sort |
Michelle H. Zonneveld |
title |
Ventricular Repolarization is Associated with Cognitive Function, but Not with Cognitive Decline and Brain Magnetic Resonance Imaging (MRI) Measurements in Older Adults |
title_short |
Ventricular Repolarization is Associated with Cognitive Function, but Not with Cognitive Decline and Brain Magnetic Resonance Imaging (MRI) Measurements in Older Adults |
title_full |
Ventricular Repolarization is Associated with Cognitive Function, but Not with Cognitive Decline and Brain Magnetic Resonance Imaging (MRI) Measurements in Older Adults |
title_fullStr |
Ventricular Repolarization is Associated with Cognitive Function, but Not with Cognitive Decline and Brain Magnetic Resonance Imaging (MRI) Measurements in Older Adults |
title_full_unstemmed |
Ventricular Repolarization is Associated with Cognitive Function, but Not with Cognitive Decline and Brain Magnetic Resonance Imaging (MRI) Measurements in Older Adults |
title_sort |
ventricular repolarization is associated with cognitive function, but not with cognitive decline and brain magnetic resonance imaging (mri) measurements in older adults |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-03-01 |
description |
We aimed to investigate the cross-sectional and longitudinal associations of electrocardiogram (ECG)-based QT, QTc, JT, JTc, and QRS intervals with cognitive function and brain magnetic resonance imaging (MRI) measurements in a cohort of older individuals at increased risk for cardiovascular disease, but free of known arrhythmias. We studied 4627 participants (54% female, mean age 75 years) enrolled in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Ten-second ECGs were conducted at baseline. Cognitive function was tested at baseline and repeated during a mean follow-up time of 3.2 years. Structural MRIs were conducted in a subgroup of 535 participants. Analyses were performed with multivariable (repeated) linear regression models and adjusted for cardiovascular risk-factors, co-morbidities, and cardiovascular drug use. At baseline, longer QT, JT, JTc—but not QTc and QRS intervals—were associated with a worse cognitive performance. Most notably, on the Stroop Test, participants performed 3.02 (95% CI 0.31; 5.73) seconds worse per standard deviation higher QT interval, independent of cardiovascular risk factors and medication use. There was no association between longer ventricular de- or repolarization and structural brain measurements. Therefore, specifically ventricular repolarization was associated with worse cognitive performance in older individuals at baseline but not during follow-up. |
topic |
older adults cardiovascular disease cognitive dysfunction mri prolonged qt interval |
url |
https://www.mdpi.com/2077-0383/9/4/911 |
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