Ionic Liquids in Drug Delivery
Ionic liquids (ILs) are molten salts composed of a large organic cation and an organic/inorganic anion. Due to their ionic character, most ILs present advantageous properties over conventional solvents, such as negligible volatility at atmospheric conditions and high thermal and chemical stabilities...
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doaj-a206eb257a5a426595cf524c3c3e83a62021-09-09T13:42:27ZengMDPI AGEncyclopedia2673-83922021-04-0112732433910.3390/encyclopedia1020027Ionic Liquids in Drug DeliverySónia N. Pedro0Carmen S. R. Freire1Armando J. D. Silvestre2Mara G. Freire3Department of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, PortugalDepartment of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, PortugalDepartment of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, PortugalDepartment of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, PortugalIonic liquids (ILs) are molten salts composed of a large organic cation and an organic/inorganic anion. Due to their ionic character, most ILs present advantageous properties over conventional solvents, such as negligible volatility at atmospheric conditions and high thermal and chemical stabilities. The wide variety of IL anion–cation combinations allows these solvents to be designed to display a strong solvation ability for a myriad of active pharmaceutical ingredients (APIs) and (bio)polymers. Given these properties, ILs have been used as solvents and as formulation components in different areas of drug delivery, as well as novel liquid forms of APIs (API-ILs) applied in different stages of development of novel drug delivery systems. Furthermore, their combination with polymers and biopolymers has enabled the design of drug delivery systems for new therapeutic routes of administration.https://www.mdpi.com/2673-8392/1/2/27active pharmaceutical ingredientsdrug deliveryformulationsionic liquidspermeation enhancersstimuli-responsive systems |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sónia N. Pedro Carmen S. R. Freire Armando J. D. Silvestre Mara G. Freire |
spellingShingle |
Sónia N. Pedro Carmen S. R. Freire Armando J. D. Silvestre Mara G. Freire Ionic Liquids in Drug Delivery Encyclopedia active pharmaceutical ingredients drug delivery formulations ionic liquids permeation enhancers stimuli-responsive systems |
author_facet |
Sónia N. Pedro Carmen S. R. Freire Armando J. D. Silvestre Mara G. Freire |
author_sort |
Sónia N. Pedro |
title |
Ionic Liquids in Drug Delivery |
title_short |
Ionic Liquids in Drug Delivery |
title_full |
Ionic Liquids in Drug Delivery |
title_fullStr |
Ionic Liquids in Drug Delivery |
title_full_unstemmed |
Ionic Liquids in Drug Delivery |
title_sort |
ionic liquids in drug delivery |
publisher |
MDPI AG |
series |
Encyclopedia |
issn |
2673-8392 |
publishDate |
2021-04-01 |
description |
Ionic liquids (ILs) are molten salts composed of a large organic cation and an organic/inorganic anion. Due to their ionic character, most ILs present advantageous properties over conventional solvents, such as negligible volatility at atmospheric conditions and high thermal and chemical stabilities. The wide variety of IL anion–cation combinations allows these solvents to be designed to display a strong solvation ability for a myriad of active pharmaceutical ingredients (APIs) and (bio)polymers. Given these properties, ILs have been used as solvents and as formulation components in different areas of drug delivery, as well as novel liquid forms of APIs (API-ILs) applied in different stages of development of novel drug delivery systems. Furthermore, their combination with polymers and biopolymers has enabled the design of drug delivery systems for new therapeutic routes of administration. |
topic |
active pharmaceutical ingredients drug delivery formulations ionic liquids permeation enhancers stimuli-responsive systems |
url |
https://www.mdpi.com/2673-8392/1/2/27 |
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