Potentiation of Lupus Activity by Granulocyte Colony-Stimulating Factor

• Main Authors: Tsz Ching Mok, Lok Ping Ng, Eva Tsz Fung Chui, Ho Yin Chung
• Format: Article
• Language: English
• Published: World Scientific Publishing 2021-07-01
• Series: Journal of Clinical Rheumatology and Immunology
• Subjects: granulocyte colony-stimulating factor; systemic lupus erythematosus; leucopenia; cytokine storm syndrome; azathioprine
• Online Access: http://www.worldscientific.com/doi/epdf/10.1142/S2661341721720019
• ISSN: 2661-3417; 2661-3425

Recombinant human granulocyte colony-stimulating factor (G-CSF) is commonly used to accelerate recovery of neutropenia in patients with marrow suppression. We hereby report a patient with systemic lupus erythematosus (SLE) who developed diffuse lupus nephritis and impending cytokine storm after G-CSF therapy. The exact mechanisms by which G-CSF leads to lupus flares remains enigmatic. Increased neutrophil apoptosis and release of cytokines have been postulated. The use of G-CSF in patients with autoimmune disease should be cautious.