The risk of cognitive impairment associated with hearing function in older adults: a pooled analysis of data from eleven studies
Abstract Impaired hearing and cognition are disabling conditions among older adults. Research has presented inconsistent conclusions regarding hearing impairment posing a risk for cognitive impairment. We aimed to assess this from published evidence via searching PubMed and Embase, from the inceptio...
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2018-02-01
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doaj-a22a621c8e484b459d8056acd30d26602020-12-08T04:43:07ZengNature Publishing GroupScientific Reports2045-23222018-02-018111010.1038/s41598-018-20496-wThe risk of cognitive impairment associated with hearing function in older adults: a pooled analysis of data from eleven studiesJing Yuan0Yu Sun1Shuping Sang2Jessica Huynh Pham3Wei-Jia Kong4Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologySchool of Medicine, Yunnan UniversitySchool of Medicine, Case Western Reserve University, ClevelandDepartment of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Impaired hearing and cognition are disabling conditions among older adults. Research has presented inconsistent conclusions regarding hearing impairment posing a risk for cognitive impairment. We aimed to assess this from published evidence via searching PubMed and Embase, from the inception of the databases indexed to December 2, 2016. For those high-quality studies retrieved, relative risk (RR) and 95% confidence intervals (CIs) were combined to estimate the risk of cognitive impairment. Eleven cohort studies were included in the present study. Pooled results found that elderly people with disabled peripheral and central hearing function had a higher risk of cognitive impairment (for moderate/severe peripheral hearing impairment: RR = 1.29, 95% CI: 1.04–1.59 during a follow-up ≤6 years. RR = 1.57, 95% CI: 1.13–2.20 during a follow-up >6 years; for severe central hearing impairment, RR = 3.21, 95% CI: 1.19–8.69) compared to those with normal hearing function. We also recorded a dose-response trend for cognitive impairment as hearing thresholds rose. No evident bias from potential confounding factors was found with one exception: the length for clinical follow-up. Although results are preliminary because qualifying studies were few, statistical findings were consistent with older people identified as having greater levels of hearing loss, having a corresponding higher risk of cognitive impairment.https://doi.org/10.1038/s41598-018-20496-w |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jing Yuan Yu Sun Shuping Sang Jessica Huynh Pham Wei-Jia Kong |
spellingShingle |
Jing Yuan Yu Sun Shuping Sang Jessica Huynh Pham Wei-Jia Kong The risk of cognitive impairment associated with hearing function in older adults: a pooled analysis of data from eleven studies Scientific Reports |
author_facet |
Jing Yuan Yu Sun Shuping Sang Jessica Huynh Pham Wei-Jia Kong |
author_sort |
Jing Yuan |
title |
The risk of cognitive impairment associated with hearing function in older adults: a pooled analysis of data from eleven studies |
title_short |
The risk of cognitive impairment associated with hearing function in older adults: a pooled analysis of data from eleven studies |
title_full |
The risk of cognitive impairment associated with hearing function in older adults: a pooled analysis of data from eleven studies |
title_fullStr |
The risk of cognitive impairment associated with hearing function in older adults: a pooled analysis of data from eleven studies |
title_full_unstemmed |
The risk of cognitive impairment associated with hearing function in older adults: a pooled analysis of data from eleven studies |
title_sort |
risk of cognitive impairment associated with hearing function in older adults: a pooled analysis of data from eleven studies |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2018-02-01 |
description |
Abstract Impaired hearing and cognition are disabling conditions among older adults. Research has presented inconsistent conclusions regarding hearing impairment posing a risk for cognitive impairment. We aimed to assess this from published evidence via searching PubMed and Embase, from the inception of the databases indexed to December 2, 2016. For those high-quality studies retrieved, relative risk (RR) and 95% confidence intervals (CIs) were combined to estimate the risk of cognitive impairment. Eleven cohort studies were included in the present study. Pooled results found that elderly people with disabled peripheral and central hearing function had a higher risk of cognitive impairment (for moderate/severe peripheral hearing impairment: RR = 1.29, 95% CI: 1.04–1.59 during a follow-up ≤6 years. RR = 1.57, 95% CI: 1.13–2.20 during a follow-up >6 years; for severe central hearing impairment, RR = 3.21, 95% CI: 1.19–8.69) compared to those with normal hearing function. We also recorded a dose-response trend for cognitive impairment as hearing thresholds rose. No evident bias from potential confounding factors was found with one exception: the length for clinical follow-up. Although results are preliminary because qualifying studies were few, statistical findings were consistent with older people identified as having greater levels of hearing loss, having a corresponding higher risk of cognitive impairment. |
url |
https://doi.org/10.1038/s41598-018-20496-w |
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