Regulatory T-Cell-Associated Cytokines in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production, complement activation, and immune complex deposition, resulting in tissue and organ damage. An understanding of the mechanisms responsible for homeostatic control of inflammation, which involve both...
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doaj-a234c8e7c8454220af4728acedb94ea92020-11-25T02:11:49ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512011-01-01201110.1155/2011/463412463412Regulatory T-Cell-Associated Cytokines in Systemic Lupus ErythematosusAkiko Okamoto0Keishi Fujio1Tomohisa Okamura2Kazuhiko Yamamoto3Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, JapanDepartment of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, JapanDepartment of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, JapanDepartment of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, JapanSystemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production, complement activation, and immune complex deposition, resulting in tissue and organ damage. An understanding of the mechanisms responsible for homeostatic control of inflammation, which involve both innate and adoptive immune responses, will enable the development of novel therapies for SLE. Regulatory T cells (Treg) play critical roles in the induction of peripheral tolerance to self- and foreign antigens. Naturally occurring CD4+CD25+ Treg, which characteristically express the transcription factor forkhead box protein P3 (Foxp3), have been intensively studied because their deficiency abrogates self-tolerance and causes autoimmune disease. Moreover, regulatory cytokines such as interleukin-10 (IL-10) also play a central role in controlling inflammatory processes. This paper focuses on Tregs and Treg-associated cytokines which might regulate the pathogenesis of SLE and, hence, have clinical applications.http://dx.doi.org/10.1155/2011/463412 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Akiko Okamoto Keishi Fujio Tomohisa Okamura Kazuhiko Yamamoto |
spellingShingle |
Akiko Okamoto Keishi Fujio Tomohisa Okamura Kazuhiko Yamamoto Regulatory T-Cell-Associated Cytokines in Systemic Lupus Erythematosus Journal of Biomedicine and Biotechnology |
author_facet |
Akiko Okamoto Keishi Fujio Tomohisa Okamura Kazuhiko Yamamoto |
author_sort |
Akiko Okamoto |
title |
Regulatory T-Cell-Associated Cytokines in Systemic Lupus Erythematosus |
title_short |
Regulatory T-Cell-Associated Cytokines in Systemic Lupus Erythematosus |
title_full |
Regulatory T-Cell-Associated Cytokines in Systemic Lupus Erythematosus |
title_fullStr |
Regulatory T-Cell-Associated Cytokines in Systemic Lupus Erythematosus |
title_full_unstemmed |
Regulatory T-Cell-Associated Cytokines in Systemic Lupus Erythematosus |
title_sort |
regulatory t-cell-associated cytokines in systemic lupus erythematosus |
publisher |
Hindawi Limited |
series |
Journal of Biomedicine and Biotechnology |
issn |
1110-7243 1110-7251 |
publishDate |
2011-01-01 |
description |
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production, complement activation, and immune complex deposition, resulting in tissue and organ damage. An understanding of the mechanisms responsible for homeostatic control of inflammation, which involve both innate and adoptive immune responses, will enable the development of novel therapies for SLE. Regulatory T cells (Treg) play critical roles in the induction of peripheral tolerance to self- and foreign antigens. Naturally occurring CD4+CD25+ Treg, which characteristically express the transcription factor forkhead box protein P3 (Foxp3), have been intensively studied because their deficiency abrogates self-tolerance and causes autoimmune disease. Moreover, regulatory cytokines such as interleukin-10 (IL-10) also play a central role in controlling inflammatory processes. This paper focuses on Tregs and Treg-associated cytokines which might regulate the pathogenesis of SLE and, hence, have clinical applications. |
url |
http://dx.doi.org/10.1155/2011/463412 |
work_keys_str_mv |
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