Mushroom Lectins: Specificity, Structure and Bioactivity Relevant to Human Disease
Lectins are non-immunoglobulin proteins that bind diverse sugar structures with a high degree of selectivity. Lectins play crucial role in various biological processes such as cellular signaling, scavenging of glycoproteins from the circulatory system, cell–cell interactions in the immune system, di...
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doaj-a2366a307ca34953aa2c01bad65344662020-11-24T22:22:58ZengMDPI AGInternational Journal of Molecular Sciences1422-00672015-04-011647802783810.3390/ijms16047802ijms16047802Mushroom Lectins: Specificity, Structure and Bioactivity Relevant to Human DiseaseMohamed Ali Abol Hassan0Razina Rouf1Evelin Tiralongo2Tom W. May3Joe Tiralongo4Institute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD 4222, AustraliaInstitute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD 4222, AustraliaSchool of Pharmacy and Griffith Health Institute, Griffith University, Gold Coast Campus, Gold Coast, QLD 4222, AustraliaRoyal Botanic Gardens Melbourne, South Yarra, VIC 3141, AustraliaInstitute for Glycomics, Griffith University, Gold Coast Campus, Gold Coast, QLD 4222, AustraliaLectins are non-immunoglobulin proteins that bind diverse sugar structures with a high degree of selectivity. Lectins play crucial role in various biological processes such as cellular signaling, scavenging of glycoproteins from the circulatory system, cell–cell interactions in the immune system, differentiation and protein targeting to cellular compartments, as well as in host defence mechanisms, inflammation, and cancer. Among all the sources of lectins, plants have been most extensively studied. However, more recently fungal lectins have attracted considerable attention due to their antitumor, antiproliferative and immunomodulatory activities. Given that only 10% of mushroom species are known and have been taxonomically classified, mushrooms represent an enormous unexplored source of potentially useful and novel lectins. In this review we provide an up-to-date summary on the biochemical, molecular and structural properties of mushroom lectins, as well as their versatile applications specifically focusing on mushroom lectin bioactivity.http://www.mdpi.com/1422-0067/16/4/7802lectinsmushroomsbioactivitystructureantiproliferative activityimmunomodulatory activityantiviral activity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohamed Ali Abol Hassan Razina Rouf Evelin Tiralongo Tom W. May Joe Tiralongo |
spellingShingle |
Mohamed Ali Abol Hassan Razina Rouf Evelin Tiralongo Tom W. May Joe Tiralongo Mushroom Lectins: Specificity, Structure and Bioactivity Relevant to Human Disease International Journal of Molecular Sciences lectins mushrooms bioactivity structure antiproliferative activity immunomodulatory activity antiviral activity |
author_facet |
Mohamed Ali Abol Hassan Razina Rouf Evelin Tiralongo Tom W. May Joe Tiralongo |
author_sort |
Mohamed Ali Abol Hassan |
title |
Mushroom Lectins: Specificity, Structure and Bioactivity Relevant to Human Disease |
title_short |
Mushroom Lectins: Specificity, Structure and Bioactivity Relevant to Human Disease |
title_full |
Mushroom Lectins: Specificity, Structure and Bioactivity Relevant to Human Disease |
title_fullStr |
Mushroom Lectins: Specificity, Structure and Bioactivity Relevant to Human Disease |
title_full_unstemmed |
Mushroom Lectins: Specificity, Structure and Bioactivity Relevant to Human Disease |
title_sort |
mushroom lectins: specificity, structure and bioactivity relevant to human disease |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2015-04-01 |
description |
Lectins are non-immunoglobulin proteins that bind diverse sugar structures with a high degree of selectivity. Lectins play crucial role in various biological processes such as cellular signaling, scavenging of glycoproteins from the circulatory system, cell–cell interactions in the immune system, differentiation and protein targeting to cellular compartments, as well as in host defence mechanisms, inflammation, and cancer. Among all the sources of lectins, plants have been most extensively studied. However, more recently fungal lectins have attracted considerable attention due to their antitumor, antiproliferative and immunomodulatory activities. Given that only 10% of mushroom species are known and have been taxonomically classified, mushrooms represent an enormous unexplored source of potentially useful and novel lectins. In this review we provide an up-to-date summary on the biochemical, molecular and structural properties of mushroom lectins, as well as their versatile applications specifically focusing on mushroom lectin bioactivity. |
topic |
lectins mushrooms bioactivity structure antiproliferative activity immunomodulatory activity antiviral activity |
url |
http://www.mdpi.com/1422-0067/16/4/7802 |
work_keys_str_mv |
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1725766475795398656 |