Doxorubicin Induced Nephrotoxicity: Protective Effect of Nicotinamide
Introduction. Nephrotoxicity is one of the important side effects of anthracycline antibiotics. The aim of this study was to investigate the effects of nicotinamide (NAD), an antioxidant agent, against nephrotoxicity induced by doxorubicin (DXR). Methods. The rats were divided into control, NAD alon...
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doaj-a23cd597165b49e49adc4b7cb253635c2020-11-24T22:20:45ZengHindawi LimitedInternational Journal of Cell Biology1687-88761687-88842011-01-01201110.1155/2011/390238390238Doxorubicin Induced Nephrotoxicity: Protective Effect of NicotinamideSule Ayla0Ismail Seckin1Gamze Tanriverdi2Mujgan Cengiz3Mediha Eser4B. C. Soner5Gulperi Oktem6Suleymaniye Woman Health Hospital, 34122 Istanbul, TurkeyDepartment of Histology and Embryology, Cerrahpasa School of Medicine, Istanbul University, 34452 Istanbul, TurkeyDepartment of Histology and Embryology, Cerrahpasa School of Medicine, Istanbul University, 34452 Istanbul, TurkeyDepartment of Medical Biology, Cerrahpasa School of Medicine, Istanbul University, 34452 Istanbul, TurkeyDepartment of Medical Biology, Cerrahpasa School of Medicine, Istanbul University, 34452 Istanbul, TurkeyDepartment of Pharmacology, Meram School of Medicine, Selcuk University, 42080 Konya, TurkeyDepartment of Histology and Embryology, Ege University School of Medicine, 35100 Izmir, TurkeyIntroduction. Nephrotoxicity is one of the important side effects of anthracycline antibiotics. The aim of this study was to investigate the effects of nicotinamide (NAD), an antioxidant agent, against nephrotoxicity induced by doxorubicin (DXR). Methods. The rats were divided into control, NAD alone, doxorubicin (20 mg/kg, i.p.) and DXR plus NAD (200 mg/kg, i.p.) groups. At the end of the 10th day, kidney tissues were removed for light microscopy and analysis. The level of tissues' catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), inducible nitric oxide (iNOS) and endothelial nitric oxide (eNOS) activities were determined. Results. The activities of CAT, GPx, and GSH were decreased, and Po was increased in renal tissue of doxorubicin group compared with other groups. The tissue of the doxorubicin group showed some histopathological changes such as glomerular vacuolization and degeneration, adhesion to Bowman's capsule and thickening and untidiness of tubular and glomerular capillary basement membranes. Histopathological examination showed that NAD prevented partly DXR-induced tubular and glomerular damage. Conclusions. Pretreatment with NAD protected renal tissues against DXR-induced nephrotoxicity. Preventive effects of NAD on these renal lesions may be via its antioxidant and anti-inflammatory action.http://dx.doi.org/10.1155/2011/390238 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sule Ayla Ismail Seckin Gamze Tanriverdi Mujgan Cengiz Mediha Eser B. C. Soner Gulperi Oktem |
spellingShingle |
Sule Ayla Ismail Seckin Gamze Tanriverdi Mujgan Cengiz Mediha Eser B. C. Soner Gulperi Oktem Doxorubicin Induced Nephrotoxicity: Protective Effect of Nicotinamide International Journal of Cell Biology |
author_facet |
Sule Ayla Ismail Seckin Gamze Tanriverdi Mujgan Cengiz Mediha Eser B. C. Soner Gulperi Oktem |
author_sort |
Sule Ayla |
title |
Doxorubicin Induced Nephrotoxicity: Protective Effect of Nicotinamide |
title_short |
Doxorubicin Induced Nephrotoxicity: Protective Effect of Nicotinamide |
title_full |
Doxorubicin Induced Nephrotoxicity: Protective Effect of Nicotinamide |
title_fullStr |
Doxorubicin Induced Nephrotoxicity: Protective Effect of Nicotinamide |
title_full_unstemmed |
Doxorubicin Induced Nephrotoxicity: Protective Effect of Nicotinamide |
title_sort |
doxorubicin induced nephrotoxicity: protective effect of nicotinamide |
publisher |
Hindawi Limited |
series |
International Journal of Cell Biology |
issn |
1687-8876 1687-8884 |
publishDate |
2011-01-01 |
description |
Introduction. Nephrotoxicity is one of the important side effects of anthracycline antibiotics. The aim of this study was to investigate the effects of nicotinamide (NAD), an antioxidant agent, against nephrotoxicity induced by doxorubicin (DXR).
Methods. The rats were divided into control, NAD alone, doxorubicin (20 mg/kg, i.p.) and DXR plus NAD (200 mg/kg, i.p.) groups. At the end of the 10th day, kidney tissues were removed for light microscopy and analysis. The level of tissues' catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), inducible nitric oxide (iNOS) and endothelial nitric oxide (eNOS) activities were determined. Results. The activities of CAT, GPx, and GSH were decreased, and Po was increased in renal tissue of doxorubicin group compared with other groups. The tissue of the doxorubicin group showed some histopathological changes such as glomerular vacuolization and degeneration, adhesion to Bowman's capsule and thickening and untidiness of tubular and glomerular capillary basement membranes. Histopathological examination showed that NAD prevented partly DXR-induced tubular and glomerular damage. Conclusions. Pretreatment with NAD protected renal tissues against DXR-induced nephrotoxicity. Preventive effects of NAD on these renal lesions may be via its antioxidant and anti-inflammatory action. |
url |
http://dx.doi.org/10.1155/2011/390238 |
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