The Hitchhiker Guide to CD4+ T-Cell Depletion in Lentiviral Infection. A Critical Review of the Dynamics of the CD4+ T Cells in SIV and HIV Infection

The Hitchhiker Guide to CD4+ T-Cell Depletion in Lentiviral Infection. A Critical Review of the Dynamics of the CD4+ T Cells in SIV and HIV Infection

CD4+ T-cell depletion is pathognomonic for AIDS in both HIV and simian immunodeficiency virus (SIV) infections. It occurs early, is massive at mucosal sites, and is not entirely reverted by antiretroviral therapy (ART), particularly if initiated when T-cell functions are compromised. HIV/SIV infect...

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Bibliographic Details
Main Authors: Quentin Le Hingrat, Irini Sereti, Alan L. Landay, Ivona Pandrea, Cristian Apetrei
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
human immunodeficiency virus
simian immunodeficiency virus (SIV)
AIDS
microbial translocation
immune activation (IA)
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.695674/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.695674/full

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