Simultaneous Determination of A Novel Antitrypanosomal Compound (OSU-36) and its Ester Derivative (OSU-40) in Plasma by HPLC: Application to First Pharmacokinetic Study in Rats
Purpose. To develop an HPLC-UV method for determination of a novel antitrypanosomal compound (OSU-36) and its ester prodrug (OSU-40) in rat plasma and to apply the method for pharmacokinetic evaluation of both compounds in rats. Methods. Since an attempt to assay for OSU-36 and OSU-40 in non-stabili...
Main Authors: | Pavel Gershkovich, Kishor M. Wasan, Olena Sivak, Summer Lysakowski, Carolyn Reid, Kokku Premalatha, Karl A. Werbovetz |
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Format: | Article |
Language: | English |
Published: |
Canadian Society for Pharmaceutical Sciences
2011-01-01
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Series: | Journal of Pharmacy & Pharmaceutical Sciences |
Online Access: | https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/9374 |
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