Notoginsenoside R1–Induced Neuronal Repair in Models of Alzheimer Disease Is Associated With an Alteration in Neuronal Hyperexcitability, Which Is Regulated by Nav

Notoginsenoside R1–Induced Neuronal Repair in Models of Alzheimer Disease Is Associated With an Alteration in Neuronal Hyperexcitability, Which Is Regulated by Nav

Alzheimer disease is characterized by a progressive cognitive deficit and may be associated with an aberrant hyperexcitability of the neuronal network. Notoginsenoside R1 (R1), a major activity ingredient from Panax notoginseng, has demonstrated favorable changes in neuronal plasticity and induced n...

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Bibliographic Details
Main Authors: Tao Hu, Shan Li, Wen-Qi Liang, Shan-Shan Li, Min-Nan Lu, Bo Chen, Li Zhang, Rui Mao, Wan-Hai Ding, Wen-Wei Gao, Shi-Wen Chen, Yan-Bin XiYang, Jie Zhang, Xu-Yang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
notoginsenoside R1
Alzheimer disease
neuronal hyperexcitability
voltage-gated sodium channel
cognitive impairment
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00280/full

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https://www.frontiersin.org/article/10.3389/fncel.2020.00280/full

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