Clinical Characteristics of Asymptomatic and Symptomatic Pediatric Coronavirus Disease 2019 (COVID-19): A Systematic Review
<i>Background and objectives:</i> Characterization of pediatric coronavirus disease 2019 (COVID-19) is necessary to control the pandemic, as asymptomatic or mildly infected children may act as carriers. To date, there are limited reports describing differences in clinical, laboratory, an...
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doaj-a24effe784d74cdd90779ea8cc4d33252020-11-25T03:33:11ZengMDPI AGMedicina1010-660X2020-09-015647447410.3390/medicina56090474Clinical Characteristics of Asymptomatic and Symptomatic Pediatric Coronavirus Disease 2019 (COVID-19): A Systematic ReviewSojung Yoon0Han Li1Keum Hwa Lee2Sung Hwi Hong3Dohoon Kim4Hyunjoon Im5Woongchan Rah6Eunseol Kim7Seungyeon Cha8Jinho Yang9Andreas Kronbichler10Daniela Kresse11Ai Koyanagi12Louis Jacob13Ramy Abou Ghayda14Jae Il Shin15Lee Smith16College of Medicine, Yonsei University, Seoul 03722, KoreaCollege of Medicine, University of Florida, Gainesville, FL 32610, USADepartment of Pediatrics, College of Medicine, Yonsei University, Seoul 03722, KoreaCollege of Medicine, Yonsei University, Seoul 03722, KoreaCollege of Medicine, Yonsei University, Seoul 03722, KoreaCollege of Medicine, Yonsei University, Seoul 03722, KoreaCollege of Medicine, Yonsei University, Seoul 03722, KoreaCollege of Medicine, Yonsei University, Seoul 03722, KoreaCollege of Medicine, Yonsei University, Seoul 03722, KoreaCollege of Medicine, Yonsei University, Seoul 03722, KoreaDepartment of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, 6020 Innsbruck, AustriaDepartment of Internal Medicine, St. Johann County Hospital, 6380 St. Johann, AustriaResearch and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, 08830 Barcelona, SpainResearch and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, 08830 Barcelona, SpainDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USADepartment of Pediatrics, College of Medicine, Yonsei University, Seoul 03722, KoreaThe Cambridge Centre for Sport and Exercise Science, Anglia Ruskin University, Cambridge CB1 1PT, UK<i>Background and objectives:</i> Characterization of pediatric coronavirus disease 2019 (COVID-19) is necessary to control the pandemic, as asymptomatic or mildly infected children may act as carriers. To date, there are limited reports describing differences in clinical, laboratory, and radiological characteristics between asymptomatic and symptomatic infection, and between younger and older pediatric patients. The objective of this study is to compare characteristics among: (1) asymptomatic versus symptomatic and (2) less than 10 versus greater or equal to 10 years old pediatric COVID-19 patients. <i>Materials and Methods:</i> We searched for all terms related to pediatric COVID-19 in electronic databases (Embase, Medline, PubMed, and Web of Science) for articles from January 2020. This protocol followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. <i>Results:</i> Eligible study designs included case reports and series, while we excluded comments/letters, reviews, and literature not written in English. Initially, 817 articles were identified. Forty-three articles encompassing 158 confirmed pediatric COVID-19 cases were included in the final analyses. Lymphocytosis and high CRP were associated with symptomatic infection. Abnormal chest CT more accurately detected asymptomatic COVID-19 in older patients than in younger ones, but clinical characteristics were similar between older and younger patients. <i>Conclusions:</i> Chest CT scan findings are untrustworthy in younger children with COVID-19 as compared with clinical findings, or significant differences in findings between asymptomatic to symptomatic children. Further studies evaluating pediatric COVID-19 could contribute to potential therapeutic interventions and preventive strategies to limit spreading.https://www.mdpi.com/1010-660X/56/9/474coronavirus disease 2019 (COVID-19)novel coronavirus 2019SARS-CoV-2asymptomaticchildinfant |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sojung Yoon Han Li Keum Hwa Lee Sung Hwi Hong Dohoon Kim Hyunjoon Im Woongchan Rah Eunseol Kim Seungyeon Cha Jinho Yang Andreas Kronbichler Daniela Kresse Ai Koyanagi Louis Jacob Ramy Abou Ghayda Jae Il Shin Lee Smith |
spellingShingle |
Sojung Yoon Han Li Keum Hwa Lee Sung Hwi Hong Dohoon Kim Hyunjoon Im Woongchan Rah Eunseol Kim Seungyeon Cha Jinho Yang Andreas Kronbichler Daniela Kresse Ai Koyanagi Louis Jacob Ramy Abou Ghayda Jae Il Shin Lee Smith Clinical Characteristics of Asymptomatic and Symptomatic Pediatric Coronavirus Disease 2019 (COVID-19): A Systematic Review Medicina coronavirus disease 2019 (COVID-19) novel coronavirus 2019 SARS-CoV-2 asymptomatic child infant |
author_facet |
Sojung Yoon Han Li Keum Hwa Lee Sung Hwi Hong Dohoon Kim Hyunjoon Im Woongchan Rah Eunseol Kim Seungyeon Cha Jinho Yang Andreas Kronbichler Daniela Kresse Ai Koyanagi Louis Jacob Ramy Abou Ghayda Jae Il Shin Lee Smith |
author_sort |
Sojung Yoon |
title |
Clinical Characteristics of Asymptomatic and Symptomatic Pediatric Coronavirus Disease 2019 (COVID-19): A Systematic Review |
title_short |
Clinical Characteristics of Asymptomatic and Symptomatic Pediatric Coronavirus Disease 2019 (COVID-19): A Systematic Review |
title_full |
Clinical Characteristics of Asymptomatic and Symptomatic Pediatric Coronavirus Disease 2019 (COVID-19): A Systematic Review |
title_fullStr |
Clinical Characteristics of Asymptomatic and Symptomatic Pediatric Coronavirus Disease 2019 (COVID-19): A Systematic Review |
title_full_unstemmed |
Clinical Characteristics of Asymptomatic and Symptomatic Pediatric Coronavirus Disease 2019 (COVID-19): A Systematic Review |
title_sort |
clinical characteristics of asymptomatic and symptomatic pediatric coronavirus disease 2019 (covid-19): a systematic review |
publisher |
MDPI AG |
series |
Medicina |
issn |
1010-660X |
publishDate |
2020-09-01 |
description |
<i>Background and objectives:</i> Characterization of pediatric coronavirus disease 2019 (COVID-19) is necessary to control the pandemic, as asymptomatic or mildly infected children may act as carriers. To date, there are limited reports describing differences in clinical, laboratory, and radiological characteristics between asymptomatic and symptomatic infection, and between younger and older pediatric patients. The objective of this study is to compare characteristics among: (1) asymptomatic versus symptomatic and (2) less than 10 versus greater or equal to 10 years old pediatric COVID-19 patients. <i>Materials and Methods:</i> We searched for all terms related to pediatric COVID-19 in electronic databases (Embase, Medline, PubMed, and Web of Science) for articles from January 2020. This protocol followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. <i>Results:</i> Eligible study designs included case reports and series, while we excluded comments/letters, reviews, and literature not written in English. Initially, 817 articles were identified. Forty-three articles encompassing 158 confirmed pediatric COVID-19 cases were included in the final analyses. Lymphocytosis and high CRP were associated with symptomatic infection. Abnormal chest CT more accurately detected asymptomatic COVID-19 in older patients than in younger ones, but clinical characteristics were similar between older and younger patients. <i>Conclusions:</i> Chest CT scan findings are untrustworthy in younger children with COVID-19 as compared with clinical findings, or significant differences in findings between asymptomatic to symptomatic children. Further studies evaluating pediatric COVID-19 could contribute to potential therapeutic interventions and preventive strategies to limit spreading. |
topic |
coronavirus disease 2019 (COVID-19) novel coronavirus 2019 SARS-CoV-2 asymptomatic child infant |
url |
https://www.mdpi.com/1010-660X/56/9/474 |
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