The Dual-Specificity Phosphatase 10 (DUSP10): Its Role in Cancer, Inflammation, and Immunity
Cancer is one of the most diagnosed diseases in developed countries. Inflammation is a common response to different stress situations including cancer and infection. In those processes, the family of mitogen-activated protein kinases (MAPKs) has an important role regulating cytokine secretion, proli...
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doaj-a2571ee35d8447c6a34c7bb54aa68c202020-11-24T22:28:49ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-04-01207162610.3390/ijms20071626ijms20071626The Dual-Specificity Phosphatase 10 (DUSP10): Its Role in Cancer, Inflammation, and ImmunityMarta Jiménez-Martínez0Konstantinos Stamatakis1Manuel Fresno2Department of Cell Biology and Immunology, Centro de Biología Molecular ‘Severo Ochoa’ (CSIC-UAM), 28049 Madrid, SpainDepartment of Cell Biology and Immunology, Centro de Biología Molecular ‘Severo Ochoa’ (CSIC-UAM), 28049 Madrid, SpainDepartment of Cell Biology and Immunology, Centro de Biología Molecular ‘Severo Ochoa’ (CSIC-UAM), 28049 Madrid, SpainCancer is one of the most diagnosed diseases in developed countries. Inflammation is a common response to different stress situations including cancer and infection. In those processes, the family of mitogen-activated protein kinases (MAPKs) has an important role regulating cytokine secretion, proliferation, survival, and apoptosis, among others. MAPKs regulate a large number of extracellular signals upon a variety of physiological as well as pathological conditions. MAPKs activation is tightly regulated by phosphorylation/dephosphorylation events. In this regard, the dual-specificity phosphatase 10 (DUSP10) has been described as a MAPK phosphatase that negatively regulates p38 MAPK and c-Jun N-terminal kinase (JNK) in several cellular types and tissues. Several studies have proposed that extracellular signal-regulated kinase (ERK) can be also modulated by DUSP10. This suggests a complex role of DUSP10 on MAPKs regulation and, in consequence, its impact in a wide variety of responses involved in both cancer and inflammation. Here, we review DUSP10 function in cancerous and immune cells and studies in both mouse models and patients that establish a clear role of DUSP10 in different processes such as inflammation, immunity, and cancer.https://www.mdpi.com/1422-0067/20/7/1626DUSP10MAPKinflammationcancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marta Jiménez-Martínez Konstantinos Stamatakis Manuel Fresno |
spellingShingle |
Marta Jiménez-Martínez Konstantinos Stamatakis Manuel Fresno The Dual-Specificity Phosphatase 10 (DUSP10): Its Role in Cancer, Inflammation, and Immunity International Journal of Molecular Sciences DUSP10 MAPK inflammation cancer |
author_facet |
Marta Jiménez-Martínez Konstantinos Stamatakis Manuel Fresno |
author_sort |
Marta Jiménez-Martínez |
title |
The Dual-Specificity Phosphatase 10 (DUSP10): Its Role in Cancer, Inflammation, and Immunity |
title_short |
The Dual-Specificity Phosphatase 10 (DUSP10): Its Role in Cancer, Inflammation, and Immunity |
title_full |
The Dual-Specificity Phosphatase 10 (DUSP10): Its Role in Cancer, Inflammation, and Immunity |
title_fullStr |
The Dual-Specificity Phosphatase 10 (DUSP10): Its Role in Cancer, Inflammation, and Immunity |
title_full_unstemmed |
The Dual-Specificity Phosphatase 10 (DUSP10): Its Role in Cancer, Inflammation, and Immunity |
title_sort |
dual-specificity phosphatase 10 (dusp10): its role in cancer, inflammation, and immunity |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-04-01 |
description |
Cancer is one of the most diagnosed diseases in developed countries. Inflammation is a common response to different stress situations including cancer and infection. In those processes, the family of mitogen-activated protein kinases (MAPKs) has an important role regulating cytokine secretion, proliferation, survival, and apoptosis, among others. MAPKs regulate a large number of extracellular signals upon a variety of physiological as well as pathological conditions. MAPKs activation is tightly regulated by phosphorylation/dephosphorylation events. In this regard, the dual-specificity phosphatase 10 (DUSP10) has been described as a MAPK phosphatase that negatively regulates p38 MAPK and c-Jun N-terminal kinase (JNK) in several cellular types and tissues. Several studies have proposed that extracellular signal-regulated kinase (ERK) can be also modulated by DUSP10. This suggests a complex role of DUSP10 on MAPKs regulation and, in consequence, its impact in a wide variety of responses involved in both cancer and inflammation. Here, we review DUSP10 function in cancerous and immune cells and studies in both mouse models and patients that establish a clear role of DUSP10 in different processes such as inflammation, immunity, and cancer. |
topic |
DUSP10 MAPK inflammation cancer |
url |
https://www.mdpi.com/1422-0067/20/7/1626 |
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