White matter damage and systemic inflammation in Parkinson’s disease
Abstract Background Systemic inflammation and white matter (WM) alterations have been noted as effects of Parkinson’s disease (PD). This study sought to evaluate WM integrity in PD patients using diffusion tensor imaging (DTI) and to assess its relationship with systemic inflammation. Methods Sixty-...
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doaj-a25863b040d84132b05e0a09e0d432522020-11-24T20:58:33ZengBMCBMC Neuroscience1471-22022017-06-0118111110.1186/s12868-017-0367-yWhite matter damage and systemic inflammation in Parkinson’s diseasePi-Ling Chiang0Hsiu-Ling Chen1Cheng-Hsien Lu2Pei-Chin Chen3Meng-Hsiang Chen4I.-Hsiao Yang5Nai-Wen Tsai6Wei-Che Lin7Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Neurology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineAbstract Background Systemic inflammation and white matter (WM) alterations have been noted as effects of Parkinson’s disease (PD). This study sought to evaluate WM integrity in PD patients using diffusion tensor imaging (DTI) and to assess its relationship with systemic inflammation. Methods Sixty-six patients with PD (23 men and 43 women) and 67 healthy volunteers (29 men and 38 women) underwent blood sampling to quantify inflammatory markers and DTI scans to determine fiber integrity. The inflammatory markers included leukocyte apoptosis, as well as cellular and serum adhesion molecules, in each peripheral blood sample. DTI-related indices [including fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD)] were derived from DTI scans. The resulting FA maps were compared using voxel-based statistics to determine differences between the PD and control groups. The differences in the DTI indices, clinical severity, and inflammatory markers were correlated. Results Exploratory group-wise comparison between the two groups revealed that the PD patients exhibited extensive DTI index differences. Low FA accompanied by high RD and MD, without significant differences in AD, suggesting a demyelination process, were found in the parietal, occipital, cerebellar, and insular WM of the PD patients. The declined DTI indices were significantly correlated with increased clinical disease severity, adhesion molecules, and leukocyte apoptosis. Conclusions Patients with PD experience WM integrity damage in vulnerable regions, and these impairments are associated with increased disease severity and systemic inflammation. The possible interactions among them may represent variant neuronal injuries and their consequent processes in PD.http://link.springer.com/article/10.1186/s12868-017-0367-ySystemic inflammationWhite matter damageDiffusion tensor imagingParkinson’s disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pi-Ling Chiang Hsiu-Ling Chen Cheng-Hsien Lu Pei-Chin Chen Meng-Hsiang Chen I.-Hsiao Yang Nai-Wen Tsai Wei-Che Lin |
spellingShingle |
Pi-Ling Chiang Hsiu-Ling Chen Cheng-Hsien Lu Pei-Chin Chen Meng-Hsiang Chen I.-Hsiao Yang Nai-Wen Tsai Wei-Che Lin White matter damage and systemic inflammation in Parkinson’s disease BMC Neuroscience Systemic inflammation White matter damage Diffusion tensor imaging Parkinson’s disease |
author_facet |
Pi-Ling Chiang Hsiu-Ling Chen Cheng-Hsien Lu Pei-Chin Chen Meng-Hsiang Chen I.-Hsiao Yang Nai-Wen Tsai Wei-Che Lin |
author_sort |
Pi-Ling Chiang |
title |
White matter damage and systemic inflammation in Parkinson’s disease |
title_short |
White matter damage and systemic inflammation in Parkinson’s disease |
title_full |
White matter damage and systemic inflammation in Parkinson’s disease |
title_fullStr |
White matter damage and systemic inflammation in Parkinson’s disease |
title_full_unstemmed |
White matter damage and systemic inflammation in Parkinson’s disease |
title_sort |
white matter damage and systemic inflammation in parkinson’s disease |
publisher |
BMC |
series |
BMC Neuroscience |
issn |
1471-2202 |
publishDate |
2017-06-01 |
description |
Abstract Background Systemic inflammation and white matter (WM) alterations have been noted as effects of Parkinson’s disease (PD). This study sought to evaluate WM integrity in PD patients using diffusion tensor imaging (DTI) and to assess its relationship with systemic inflammation. Methods Sixty-six patients with PD (23 men and 43 women) and 67 healthy volunteers (29 men and 38 women) underwent blood sampling to quantify inflammatory markers and DTI scans to determine fiber integrity. The inflammatory markers included leukocyte apoptosis, as well as cellular and serum adhesion molecules, in each peripheral blood sample. DTI-related indices [including fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD)] were derived from DTI scans. The resulting FA maps were compared using voxel-based statistics to determine differences between the PD and control groups. The differences in the DTI indices, clinical severity, and inflammatory markers were correlated. Results Exploratory group-wise comparison between the two groups revealed that the PD patients exhibited extensive DTI index differences. Low FA accompanied by high RD and MD, without significant differences in AD, suggesting a demyelination process, were found in the parietal, occipital, cerebellar, and insular WM of the PD patients. The declined DTI indices were significantly correlated with increased clinical disease severity, adhesion molecules, and leukocyte apoptosis. Conclusions Patients with PD experience WM integrity damage in vulnerable regions, and these impairments are associated with increased disease severity and systemic inflammation. The possible interactions among them may represent variant neuronal injuries and their consequent processes in PD. |
topic |
Systemic inflammation White matter damage Diffusion tensor imaging Parkinson’s disease |
url |
http://link.springer.com/article/10.1186/s12868-017-0367-y |
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