Cytoprotective Effects of Carvacrol on Cyclophosphamide Induced Hematoxicity
Cyclophosphamide (CP) is an alkylating cytotoxic drug commonly used clinically for the treatment of cancer and non-malignant diseases. However, high doses of CP causes blood and bone marrow toxicity. This study was conducted to investigate the possible protective effects of carvacrol (CAR), which...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Siirt University
2018-06-01
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| Series: | Türkiye Tarımsal Araştırmalar Dergisi |
| Subjects: | |
| Online Access: | http://dergipark.gov.tr/tutad/issue/36020/378717 |
| Summary: | Cyclophosphamide (CP) is an alkylating cytotoxic drug commonly used clinically for the treatment of cancer and
non-malignant diseases. However, high doses of CP causes blood and bone marrow toxicity. This study was conducted to
investigate the possible protective effects of carvacrol (CAR), which is the basic component of essential oils and has
antioxidant properties, in blood and bone marrow in experimental hematoxicity. In the study, 63 male Sprague-Dawley rats
were divided into 9 groups as 7 animals in each group. After receiving intracardiac blood from animals under anesthesia, the
bone marrow from the femur of the rats was carefully removed. Intraperitoneal (i.p.) CP administration reduced leukocyte
(77%, 86%), thrombocyte (30%, 35%) and bone marrow nucleated cell counts (82%, 94%), respectively, parallel to the dose
increase. Leukocyte, thrombocyte and bone marrow nucleated cell counts in CP and 5 and 10 mg kg-1 CAR administered
groups was significantly increased (p<0.001) compared to the CP alone. In the prevention of CP-induced myelosuppression
and hematoxicity, 10 mg kg-1 CAR was more protective than 5 mg kg-1 CAR. The data suggest that by modifying the CAR
dose at certain ratios, a stronger protective effect against the increased CP dose can be achieved. |
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| ISSN: | 2148-2306 2528-858X |