Genetic background influences tumour development in heterozygous Men1 knockout mice

Genetic background influences tumour development in heterozygous Men1 knockout mice

Multiple endocrine neoplasia type 1 (MEN1), an autosomal domina nt disorder caused by MEN1 germline mutations, is characterised by parathyroid, pancreati c and pituitary tumours. MEN1 mutations also cause familial isolated primary hyperparathyroi dism (FIHP), a milder condition causing hyperparathyr...

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Bibliographic Details
Main Authors: Kate E Lines, Mahsa Javid, Anita A C Reed, Gerard V Walls, Mark Stevenson, Michelle Simon, Kreepa G Kooblall, Sian E Piret, Paul T Christie, Paul J Newey, Ann-Marie Mallon, Rajesh V Thakker
Format: Article
Language:English
Published: Bioscientifica 2020-05-01
Series:Endocrine Connections
Subjects:
genetic modifiers
pancreatic neuroendocrine tumour
mouse strain
menin
pituitary
Online Access:https://ec.bioscientifica.com/view/journals/ec/9/5/EC-20-0103.xml

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https://ec.bioscientifica.com/view/journals/ec/9/5/EC-20-0103.xml

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