Effect of early hyperbaric oxygen therapy on serum indexes and erythrocyte glycometabolismm in patients with craniocerebral injury

• Main Author: Wei-Tao Zhang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-05-01
• Series: Journal of Hainan Medical University
• Subjects: Craniocerebral injury Hyperbaric oxygen Stress Erythrocyte glycometabolismm
• Online Access: http://www.hnykdxxb.com/PDF/201710/38.pdf

Objective: To study the effect of early hyperbaric oxygen therapy on serum indexes and erythrocyte glycometabolismm in patients with craniocerebral injury. Methods: Patients with craniocerebral injury treated in our hospital between May 2013 and July 2016 were retrospectively analyzed and divided into hyperbaric oxygen group and control group according to the use of hyperbaric oxygen during treatment. 1 d, 3 d, 5 d and 7 d after treatment, serum was collected to determine the levels of neuron and glial cell damage marker molecules, stress molecules and hormones as well as erythrocyte glycometabolismm key enzymes. Results: 1d after treatment, serum NGB, NSE, GFAP, S100β, SOD, GSH-PX, MDA, Cor, Ins, NE, E, PFK, G-6PD and AR levels were not significantly different between two groups of patients; 3 d, 5 d and 7 d after treatment, serum NGB, NSE, GFAP, S100β, MDA, Cor, Ins, NE, E, G-6PD and AR levels of hyperbaric oxygen group were significantly lower than those of control group while SOD, GSH-PX and PFK levels were significantly higher than those of control group. Conclusion: Early hyperbaric oxygen treatment of craniocerebral injury can reduce the neuron and glial cell injury, and improve the stress state and erythrocyte glycometabolismm.