Oxidative Stress in Bacteria and the Central Dogma of Molecular Biology
Ever since the “great oxidation event,” Earth’s cellular life forms had to cope with the danger of reactive oxygen species (ROS) affecting the integrity of biomolecules and hampering cellular metabolism circuits. Consequently, increasing ROS levels in the biosphere represented growing stress levels...
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doaj-a27c860aaedd43d182e018da712894952021-05-10T05:39:38ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-05-01810.3389/fmolb.2021.671037671037Oxidative Stress in Bacteria and the Central Dogma of Molecular BiologyMichel Fasnacht0Michel Fasnacht1Norbert Polacek2Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, SwitzerlandGraduate School for Cellular and Biomedical Sciences, University of Bern, Bern, SwitzerlandDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, SwitzerlandEver since the “great oxidation event,” Earth’s cellular life forms had to cope with the danger of reactive oxygen species (ROS) affecting the integrity of biomolecules and hampering cellular metabolism circuits. Consequently, increasing ROS levels in the biosphere represented growing stress levels and thus shaped the evolution of species. Whether the ROS were produced endogenously or exogenously, different systems evolved to remove the ROS and repair the damage they inflicted. If ROS outweigh the cell’s capacity to remove the threat, we speak of oxidative stress. The injuries through oxidative stress in cells are diverse. This article reviews the damage oxidative stress imposes on the different steps of the central dogma of molecular biology in bacteria, focusing in particular on the RNA machines involved in transcription and translation.https://www.frontiersin.org/articles/10.3389/fmolb.2021.671037/fulloxidative stressROSoxidative damageDNA damageRNA damageprotein damage |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michel Fasnacht Michel Fasnacht Norbert Polacek |
spellingShingle |
Michel Fasnacht Michel Fasnacht Norbert Polacek Oxidative Stress in Bacteria and the Central Dogma of Molecular Biology Frontiers in Molecular Biosciences oxidative stress ROS oxidative damage DNA damage RNA damage protein damage |
author_facet |
Michel Fasnacht Michel Fasnacht Norbert Polacek |
author_sort |
Michel Fasnacht |
title |
Oxidative Stress in Bacteria and the Central Dogma of Molecular Biology |
title_short |
Oxidative Stress in Bacteria and the Central Dogma of Molecular Biology |
title_full |
Oxidative Stress in Bacteria and the Central Dogma of Molecular Biology |
title_fullStr |
Oxidative Stress in Bacteria and the Central Dogma of Molecular Biology |
title_full_unstemmed |
Oxidative Stress in Bacteria and the Central Dogma of Molecular Biology |
title_sort |
oxidative stress in bacteria and the central dogma of molecular biology |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Molecular Biosciences |
issn |
2296-889X |
publishDate |
2021-05-01 |
description |
Ever since the “great oxidation event,” Earth’s cellular life forms had to cope with the danger of reactive oxygen species (ROS) affecting the integrity of biomolecules and hampering cellular metabolism circuits. Consequently, increasing ROS levels in the biosphere represented growing stress levels and thus shaped the evolution of species. Whether the ROS were produced endogenously or exogenously, different systems evolved to remove the ROS and repair the damage they inflicted. If ROS outweigh the cell’s capacity to remove the threat, we speak of oxidative stress. The injuries through oxidative stress in cells are diverse. This article reviews the damage oxidative stress imposes on the different steps of the central dogma of molecular biology in bacteria, focusing in particular on the RNA machines involved in transcription and translation. |
topic |
oxidative stress ROS oxidative damage DNA damage RNA damage protein damage |
url |
https://www.frontiersin.org/articles/10.3389/fmolb.2021.671037/full |
work_keys_str_mv |
AT michelfasnacht oxidativestressinbacteriaandthecentraldogmaofmolecularbiology AT michelfasnacht oxidativestressinbacteriaandthecentraldogmaofmolecularbiology AT norbertpolacek oxidativestressinbacteriaandthecentraldogmaofmolecularbiology |
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