Generation of a human iPSC line from a patient with Leigh syndrome caused by a mutation in the MT-ATP6 gene

Generation of a human iPSC line from a patient with Leigh syndrome caused by a mutation in the MT-ATP6 gene

Human iPSC line L749.1 was generated from fibroblasts of a patient with Leigh syndrome associated with a heteroplasmic mutation in the MT-ATP6 gene. Reprogramming factors OCT4, SOX2, CMYC and KLF4 were delivered using retroviruses.

Bibliographic Details
Main Authors: Teresa Galera-Monge, Francisco Zurita-Díaz, Cristina González-Páramos, Ana Moreno-Izquierdo, Mario F. Fraga, Agustin F. Fernández, Rafael Garesse, M. Esther Gallardo
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506116300241
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spelling doaj-a27ea553d7544efa9e6d67309c5c386f2020-11-25T00:37:39ZengElsevierStem Cell Research1873-50611876-77532016-05-0116376676910.1016/j.scr.2016.04.012Generation of a human iPSC line from a patient with Leigh syndrome caused by a mutation in the MT-ATP6 geneTeresa Galera-Monge0Francisco Zurita-Díaz1Cristina González-Páramos2Ana Moreno-Izquierdo3Mario F. Fraga4Agustin F. Fernández5Rafael Garesse6M. Esther Gallardo7Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid, SpainDepartamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid, SpainDepartamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid, SpainInstituto de Investigación Hospital 12 de Octubre (“i + 12”), Madrid, SpainNanomaterials and Nanotechnology Research Center (CINN-CSIC), SpainCancer Epigenetics Laboratory, Institute of Oncology of Asturias (IUOPA), HUCA, Universidad de Oviedo, Oviedo, SpainDepartamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid, SpainDepartamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid, SpainHuman iPSC line L749.1 was generated from fibroblasts of a patient with Leigh syndrome associated with a heteroplasmic mutation in the MT-ATP6 gene. Reprogramming factors OCT4, SOX2, CMYC and KLF4 were delivered using retroviruses.http://www.sciencedirect.com/science/article/pii/S1873506116300241
collection DOAJ
language English
format Article
sources DOAJ
author Teresa Galera-Monge
Francisco Zurita-Díaz
Cristina González-Páramos
Ana Moreno-Izquierdo
Mario F. Fraga
Agustin F. Fernández
Rafael Garesse
M. Esther Gallardo
spellingShingle Teresa Galera-Monge
Francisco Zurita-Díaz
Cristina González-Páramos
Ana Moreno-Izquierdo
Mario F. Fraga
Agustin F. Fernández
Rafael Garesse
M. Esther Gallardo
Generation of a human iPSC line from a patient with Leigh syndrome caused by a mutation in the MT-ATP6 gene
Stem Cell Research
author_facet Teresa Galera-Monge
Francisco Zurita-Díaz
Cristina González-Páramos
Ana Moreno-Izquierdo
Mario F. Fraga
Agustin F. Fernández
Rafael Garesse
M. Esther Gallardo
author_sort Teresa Galera-Monge
title Generation of a human iPSC line from a patient with Leigh syndrome caused by a mutation in the MT-ATP6 gene
title_short Generation of a human iPSC line from a patient with Leigh syndrome caused by a mutation in the MT-ATP6 gene
title_full Generation of a human iPSC line from a patient with Leigh syndrome caused by a mutation in the MT-ATP6 gene
title_fullStr Generation of a human iPSC line from a patient with Leigh syndrome caused by a mutation in the MT-ATP6 gene
title_full_unstemmed Generation of a human iPSC line from a patient with Leigh syndrome caused by a mutation in the MT-ATP6 gene
title_sort generation of a human ipsc line from a patient with leigh syndrome caused by a mutation in the mt-atp6 gene
publisher Elsevier
series Stem Cell Research
issn 1873-5061
1876-7753
publishDate 2016-05-01
description Human iPSC line L749.1 was generated from fibroblasts of a patient with Leigh syndrome associated with a heteroplasmic mutation in the MT-ATP6 gene. Reprogramming factors OCT4, SOX2, CMYC and KLF4 were delivered using retroviruses.
url http://www.sciencedirect.com/science/article/pii/S1873506116300241
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