Glutamate-Mediated Primary Somatosensory Cortex Excitability Correlated with Circulating Copper and Ceruloplasmin

Glutamate-Mediated Primary Somatosensory Cortex Excitability Correlated with Circulating Copper and Ceruloplasmin

Objective. To verify whether markers of metal homeostasis are related to a magnetoencephalographic index representative of glutamate-mediated excitability of the primary somatosensory cortex. The index is identified as the source strength of the earliest component (M20) of the somatosensory magnetic...

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Main Authors: Franca Tecchio, Giovanni Assenza, Filippo Zappasodi, Stefania Mariani, Carlo Salustri, Rosanna Squitti
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:International Journal of Alzheimer's Disease
Online Access:http://dx.doi.org/10.4061/2011/292593
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spelling doaj-a281bc69021b49ffa51fce061fee59e32020-11-24T23:41:37ZengHindawi LimitedInternational Journal of Alzheimer's Disease2090-02522011-01-01201110.4061/2011/292593292593Glutamate-Mediated Primary Somatosensory Cortex Excitability Correlated with Circulating Copper and CeruloplasminFranca Tecchio0Giovanni Assenza1Filippo Zappasodi2Stefania Mariani3Carlo Salustri4Rosanna Squitti5Laboratory for Electrophysiology for Translational neuroScience (LET'S), Istituto di Scienze e Tecnologie della Cognizione (ISTC), Consiglio Nazionale delle Ricerche (CNR), Fatebenefratelli Hospital Isola Tiberina, Rome, ItalyDepartment of Clinical Neuroscience, Institue of Neurology, Campus Bio-Medico of Rome University, Rome, ItalyDepartment of Neuroscience and Imaging, G. D'Annunzio University, Chieti, ItalyDepartment of Clinical Neuroscience, Institue of Neurology, Campus Bio-Medico of Rome University, Rome, ItalyLaboratory for Electrophysiology for Translational neuroScience (LET'S), Istituto di Scienze e Tecnologie della Cognizione (ISTC), Consiglio Nazionale delle Ricerche (CNR), Fatebenefratelli Hospital Isola Tiberina, Rome, ItalyDepartment of Clinical Neuroscience, Institue of Neurology, Campus Bio-Medico of Rome University, Rome, ItalyObjective. To verify whether markers of metal homeostasis are related to a magnetoencephalographic index representative of glutamate-mediated excitability of the primary somatosensory cortex. The index is identified as the source strength of the earliest component (M20) of the somatosensory magnetic fields (SEFs) evoked by right median nerve stimulation at wrist. Method. Thirty healthy right-handed subjects (51±22 years) were enrolled in the study. A source reconstruction algorithm was applied to assess the amount of synchronously activated neurons subtending the M20 and the following SEF component (M30), which is generated by two independent contributions of gabaergic and glutamatergic transmission. Serum copper, ceruloplasmin, iron, transferrin, transferrin saturation, and zinc levels were measured. Results. Total copper and ceruloplasmin negatively correlated with the M20 source strength. Conclusion. This pilot study suggests that higher level of body copper reserve, as marked by ceruloplasmin variations, parallels lower cortical glutamatergic responsiveness.http://dx.doi.org/10.4061/2011/292593
collection DOAJ
language English
format Article
sources DOAJ
author Franca Tecchio
Giovanni Assenza
Filippo Zappasodi
Stefania Mariani
Carlo Salustri
Rosanna Squitti
spellingShingle Franca Tecchio
Giovanni Assenza
Filippo Zappasodi
Stefania Mariani
Carlo Salustri
Rosanna Squitti
Glutamate-Mediated Primary Somatosensory Cortex Excitability Correlated with Circulating Copper and Ceruloplasmin
International Journal of Alzheimer's Disease
author_facet Franca Tecchio
Giovanni Assenza
Filippo Zappasodi
Stefania Mariani
Carlo Salustri
Rosanna Squitti
author_sort Franca Tecchio
title Glutamate-Mediated Primary Somatosensory Cortex Excitability Correlated with Circulating Copper and Ceruloplasmin
title_short Glutamate-Mediated Primary Somatosensory Cortex Excitability Correlated with Circulating Copper and Ceruloplasmin
title_full Glutamate-Mediated Primary Somatosensory Cortex Excitability Correlated with Circulating Copper and Ceruloplasmin
title_fullStr Glutamate-Mediated Primary Somatosensory Cortex Excitability Correlated with Circulating Copper and Ceruloplasmin
title_full_unstemmed Glutamate-Mediated Primary Somatosensory Cortex Excitability Correlated with Circulating Copper and Ceruloplasmin
title_sort glutamate-mediated primary somatosensory cortex excitability correlated with circulating copper and ceruloplasmin
publisher Hindawi Limited
series International Journal of Alzheimer's Disease
issn 2090-0252
publishDate 2011-01-01
description Objective. To verify whether markers of metal homeostasis are related to a magnetoencephalographic index representative of glutamate-mediated excitability of the primary somatosensory cortex. The index is identified as the source strength of the earliest component (M20) of the somatosensory magnetic fields (SEFs) evoked by right median nerve stimulation at wrist. Method. Thirty healthy right-handed subjects (51±22 years) were enrolled in the study. A source reconstruction algorithm was applied to assess the amount of synchronously activated neurons subtending the M20 and the following SEF component (M30), which is generated by two independent contributions of gabaergic and glutamatergic transmission. Serum copper, ceruloplasmin, iron, transferrin, transferrin saturation, and zinc levels were measured. Results. Total copper and ceruloplasmin negatively correlated with the M20 source strength. Conclusion. This pilot study suggests that higher level of body copper reserve, as marked by ceruloplasmin variations, parallels lower cortical glutamatergic responsiveness.
url http://dx.doi.org/10.4061/2011/292593
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