WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies.

WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies.

The WRAP53 gene gives rise to a p53 antisense transcript that regulates p53. This gene also encodes a protein that directs small Cajal body-specific RNAs to Cajal bodies. Cajal bodies are nuclear organelles involved in diverse functions such as processing ribonucleoproteins important for splicing. H...

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Bibliographic Details
Main Authors: Salah Mahmoudi, Sofia Henriksson, Irene Weibrecht, Stephen Smith, Ola Söderberg, Staffan Strömblad, Klas G Wiman, Marianne Farnebo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2970535?pdf=render

Internet

http://europepmc.org/articles/PMC2970535?pdf=render

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