Epitope-associated and specificity-focused features of EV71-neutralizing antibody repertoires from plasmablasts of infected children
Enterovirus 71 is a leading cause of hand-foot-and-mouth disease and herpangina. Here, the authors characterize a large panel of plasmablast-derived IgG mAbs that target the capsid of EV71 to identify neutralizing antibodies induced by natural infection.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2017-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00736-9 |
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Article |
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doaj-a293485c5d194c97bf8cca5e0af275ba2021-05-11T07:02:11ZengNature Publishing GroupNature Communications2041-17232017-10-018111410.1038/s41467-017-00736-9Epitope-associated and specificity-focused features of EV71-neutralizing antibody repertoires from plasmablasts of infected childrenKuan-Ying Arthur Huang0Mei-Feng Chen1Yhu-Chering Huang2Shin-Ru Shih3Cheng-Hsun Chiu4Jainn-Jim Lin5Jen-Ren Wang6Kuo-Chien Tsao7Tzou-Yien Lin8Division of Infectious Diseases, Department of Pediatrics, Chang Gung Memorial HospitalResearch Center for Emerging Viral Infections, Chang Gung UniversityDivision of Infectious Diseases, Department of Pediatrics, Chang Gung Memorial HospitalResearch Center for Emerging Viral Infections, Chang Gung UniversityDivision of Infectious Diseases, Department of Pediatrics, Chang Gung Memorial HospitalDivision of Pediatric Critical Care, Department of Pediatrics, Chang Gung Memorial HospitalDepartment of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung UniversityDepartment of Laboratory Medicine, Chang Gung Memorial HospitalDivision of Infectious Diseases, Department of Pediatrics, Chang Gung Memorial HospitalEnterovirus 71 is a leading cause of hand-foot-and-mouth disease and herpangina. Here, the authors characterize a large panel of plasmablast-derived IgG mAbs that target the capsid of EV71 to identify neutralizing antibodies induced by natural infection.https://doi.org/10.1038/s41467-017-00736-9 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kuan-Ying Arthur Huang Mei-Feng Chen Yhu-Chering Huang Shin-Ru Shih Cheng-Hsun Chiu Jainn-Jim Lin Jen-Ren Wang Kuo-Chien Tsao Tzou-Yien Lin |
| spellingShingle |
Kuan-Ying Arthur Huang Mei-Feng Chen Yhu-Chering Huang Shin-Ru Shih Cheng-Hsun Chiu Jainn-Jim Lin Jen-Ren Wang Kuo-Chien Tsao Tzou-Yien Lin Epitope-associated and specificity-focused features of EV71-neutralizing antibody repertoires from plasmablasts of infected children Nature Communications |
| author_facet |
Kuan-Ying Arthur Huang Mei-Feng Chen Yhu-Chering Huang Shin-Ru Shih Cheng-Hsun Chiu Jainn-Jim Lin Jen-Ren Wang Kuo-Chien Tsao Tzou-Yien Lin |
| author_sort |
Kuan-Ying Arthur Huang |
| title |
Epitope-associated and specificity-focused features of EV71-neutralizing antibody repertoires from plasmablasts of infected children |
| title_short |
Epitope-associated and specificity-focused features of EV71-neutralizing antibody repertoires from plasmablasts of infected children |
| title_full |
Epitope-associated and specificity-focused features of EV71-neutralizing antibody repertoires from plasmablasts of infected children |
| title_fullStr |
Epitope-associated and specificity-focused features of EV71-neutralizing antibody repertoires from plasmablasts of infected children |
| title_full_unstemmed |
Epitope-associated and specificity-focused features of EV71-neutralizing antibody repertoires from plasmablasts of infected children |
| title_sort |
epitope-associated and specificity-focused features of ev71-neutralizing antibody repertoires from plasmablasts of infected children |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-10-01 |
| description |
Enterovirus 71 is a leading cause of hand-foot-and-mouth disease and herpangina. Here, the authors characterize a large panel of plasmablast-derived IgG mAbs that target the capsid of EV71 to identify neutralizing antibodies induced by natural infection. |
| url |
https://doi.org/10.1038/s41467-017-00736-9 |
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