Synthesis and Anticancer Activity of Novel 9-<i>O</i>-Substituted Berberine Derivatives

Synthesis and Anticancer Activity of Novel 9-<i>O</i>-Substituted Berberine Derivatives

Berberine is a bioactive isoquinoline alkaloid derived from many plants. Although berberine has been shown to inhibit growth and induce apoptosis of several tumor cell lines, its poor absorption and moderate activity hamper its full therapeutic potential. Here, we describe the synthesis of a series...

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Bibliographic Details
Main Authors: Viktor Milata, Alexandra Svedova, Zuzana Barbierikova, Eva Holubkova, Ingrid Cipakova, Dana Cholujova, Jana Jakubikova, Miroslav Panik, Sona Jantova, Vlasta Brezova, Lubos Cipak
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
berberine
berberine derivatives
EPR spectroscopy
antitumor activity
cell cycle arrest
apoptosis
Online Access:https://www.mdpi.com/1422-0067/20/9/2169

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https://www.mdpi.com/1422-0067/20/9/2169

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