Current Developments of Clinical Sequencing and the Clinical Utility of Polygenic Risk Scores in Inflammatory Diseases

Current Developments of Clinical Sequencing and the Clinical Utility of Polygenic Risk Scores in Inflammatory Diseases

In this mini-review, we highlight selected research by the Deutsche Forschungsgemeinschaft (DFG) Cluster of Excellence “Precision Medicine in Chronic Inflammation” focusing on clinical sequencing and the clinical utility of polygenic risk scores as well as its implication on precision medicine in th...

Full description

Bibliographic Details
Main Authors:	Matthias Hübenthal, Britt-Sabina Löscher, Jeanette Erdmann, Andre Franke, Damian Gola, Inke R. König, Hila Emmert
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-01-01
Series:	Frontiers in Immunology
Subjects:	inflammation atopic dermatitis inflammatory bowel disease coronary artery disease genome-wide association studies polygenic risk score
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2020.577677/full

Similar Items

Polygenic Score Models for Alzheimer’s Disease: From Research to Clinical Applications
by: Xiaopu Zhou, et al.
Published: (2021-03-01)

Polygenic and miltufactorial disorders
by: Pajović Snežana B.
Published: (2007-01-01)

Improving the Utility of Polygenic Risk Scores as a Biomarker for Alzheimer’s Disease
by: Dimitrios Vlachakis, et al.
Published: (2021-06-01)

Statistical genetics and polygenic risk score for precision medicine
by: Takahiro Konuma, et al.
Published: (2021-06-01)

Empirical Bayes Estimation of Semi-parametric Hierarchical Mixture Models for Unbiased Characterization of Polygenic Disease Architectures
by: Jo Nishino, et al.
Published: (2018-04-01)

Effects of the Openness to Experience Polygenic Score on Cortical Thickness and Functional Connectivity
by: Zhiting Ren, et al.
Published: (2021-01-01)

Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese population
by: Xiaopu Zhou, et al.
Published: (2020-01-01)

Atopic Disease and Anemia in Korean Patients: Cross-Sectional Study with Propensity Score Analysis
by: Kiyon Rhew, et al.
Published: (2020-03-01)

Polygenic risk scores: from research tools to clinical instruments
by: Cathryn M. Lewis, et al.
Published: (2020-05-01)

Polygenic risk and pleiotropy in neurodegenerative diseases
by: Eftychia Bellou, et al.
Published: (2020-08-01)

Low coverage whole genome sequencing enables accurate assessment of common variants and calculation of genome-wide polygenic scores
by: Julian R. Homburger, et al.
Published: (2019-11-01)

Geographic Clustering of Polygenic Scores at Different Stages of the Life Course
by: Benjamin W. Domingue, et al.
Published: (2018-04-01)

Association of atopic dermatitis with inflammatory bowel disease: A systematic review and meta-analysis
by: Chi-Hui Wang, et al.
Published: (2020-01-01)

A linear lesion in a child with atopic dermatitis: Not a coincidence
by: Julie Van Gysel, et al.
Published: (2019-09-01)

Interactions between Polygenic Scores and Environments: Methodological and Conceptual Challenges
by: Benjamin W. Domingue, et al.
Published: (2020-09-01)

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome
by: Tom G Richardson, et al.
Published: (2019-03-01)

Potential use of clinical polygenic risk scores in psychiatry – ethical implications and communicating high polygenic risk
by: A. C. Palk, et al.
Published: (2019-02-01)

Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases
by: Heng Li, et al.
Published: (2018-10-01)

Update on Atopic Dermatitis
by: Tiago Torres, et al.
Published: (2019-09-01)

Monozygotic Twins Concordant for Common Variable Immunodeficiency: Strikingly Similar Clinical and Immune Profile Associated With a Polygenic Burden
by: Susana L. Silva, et al.
Published: (2019-11-01)

Demographic history mediates the effect of stratification on polygenic scores
by: Arslan A Zaidi, et al.
Published: (2020-11-01)

Emollient treatment of atopic dermatitis: latest evidence and clinical considerations
by: Kam Lun Hon, et al.
Published: (2018-04-01)

Polygenic Risk Scores Shed Light on the Relationship between Schizophrenia and Cognitive Functioning: Review and Meta-Analysis
by: Jasmina Mallet, et al.
Published: (2020-01-01)

Association between polygenic risk score of Alzheimer’s disease and plasma phosphorylated tau in individuals from the Alzheimer’s Disease Neuroimaging Initiative
by: Anna Zettergren, et al.
Published: (2021-01-01)

Parkinson disease polygenic risk score is associated with Parkinson disease status and age at onset but not with alpha-synuclein cerebrospinal fluid levels
by: Laura Ibanez, et al.
Published: (2017-11-01)

Clinical Response and Quality of Life in Patients with Severe Atopic Dermatitis Treated with Dupilumab: A Single-Center Real-Life Experience
by: Silvia Ferrucci, et al.
Published: (2020-03-01)

Polygenic risk scoring of human embryos: a qualitative study of media coverage
by: Tiny Pagnaer, et al.
Published: (2021-09-01)

Considering the APOE locus in Alzheimer’s disease polygenic scores in the Health and Retirement Study: a longitudinal panel study
by: Erin B. Ware, et al.
Published: (2020-11-01)

Polygenic Risk Score for Alzheimer’s Disease Is Associated With Ch4 Volume in Normal Subjects
by: Tao Wang, et al.
Published: (2019-07-01)

Highly elevated polygenic risk scores are better predictors of myocardial infarction risk early in life than later
by: Monica Isgut, et al.
Published: (2021-01-01)

Predictability of polygenic risk score for progression to dementia and its interaction with APOE ε4 in mild cognitive impairment
by: Jung-Min Pyun, et al.
Published: (2021-08-01)

Using Polygenic Scores in Social Science Research: Unraveling Childlessness
by: Renske M. Verweij, et al.
Published: (2019-11-01)

Future Preventive Gene Therapy of Polygenic Diseases from a Population Genetics Perspective
by: Roman Teo Oliynyk
Published: (2019-10-01)

Association between atopic disease and anemia in pediatrics: a cross-sectional study
by: Kiyon Rhew, et al.
Published: (2019-11-01)

Polygenic Scores for Height in Admixed Populations
by: Bárbara D. Bitarello, et al.
Published: (2020-11-01)

Atopic dermatitis: clinical phenotypes, persistence and comorbidity
by: O.P. Volosovets, et al.
Published: (2021-06-01)

Polygenic Risk Scores in Alzheimer's Disease: Current Applications and Future Directions
by: Emily Baker, et al.
Published: (2020-08-01)

Variable prediction accuracy of polygenic scores within an ancestry group
by: Hakhamanesh Mostafavi, et al.
Published: (2020-01-01)

Association between polygenic risk score and risk of myopia
by: Ghorbani Mojarrad, Neema, et al.
Published: (2019)

Fluticasone propionate for external use: pharmacological properties and clinical effectiveness
by: E. V. Dvoriankova
Published: (2021-06-01)

Cannot write session to /tmp/vufind_sessions/sess_i110rerm4gnfp6oinu2fdeq69g