A Model for Estimating Dose-Rate Effects on Cell-Killing of Human Melanoma after Boron Neutron Capture Therapy
Boron neutron capture therapy (BNCT) is a type of radiation therapy for eradicating tumor cells through a <sup>10</sup>B(n,α)<sup>7</sup>Li reaction in the presence of <sup>10</sup>B in cancer cells. When delivering a high absorbed dose to cancer cells using BNCT,...
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doaj-a2bdb2f48d914b2081f52e00cec85d7b2020-11-25T02:04:00ZengMDPI AGCells2073-44092020-04-0191117111710.3390/cells9051117A Model for Estimating Dose-Rate Effects on Cell-Killing of Human Melanoma after Boron Neutron Capture TherapyYusuke Matsuya0Hisanori Fukunaga1Motoko Omura2Hiroyuki Date3Nuclear Science and Engineering Center, Research Group for Radiation Transport Analysis, Ibaraki 319-1195, JapanDepartment of Radiation Oncology, Shonan Kamakura General Hospital, Kanagawa 247-8533, JapanDepartment of Radiation Oncology, Shonan Kamakura General Hospital, Kanagawa 247-8533, JapanFaculty of Health Sciences, Hokkaido University, Hokkaiddo 060-0812, JapanBoron neutron capture therapy (BNCT) is a type of radiation therapy for eradicating tumor cells through a <sup>10</sup>B(n,α)<sup>7</sup>Li reaction in the presence of <sup>10</sup>B in cancer cells. When delivering a high absorbed dose to cancer cells using BNCT, both the timeline of <sup>10</sup>B concentrations and the relative long dose-delivery time compared to photon therapy must be considered. Changes in radiosensitivity during such a long dose-delivery time can reduce the probability of tumor control; however, such changes have not yet been evaluated. Here, we propose an improved <i>integrated microdosimetric-kinetic model </i>that accounts for changes in microdosimetric quantities and dose rates depending on the <sup>10</sup>B concentration and investigate the cell recovery (dose-rate effects) of melanoma during BNCT irradiation. The integrated microdosimetric–kinetic model used in this study considers both sub-lethal damage repair and changes in microdosimetric quantities during irradiation. The model, coupled with the Monte Carlo track structure simulation code of the Particle and Heavy Ion Transport code System, shows good agreement with <i>in vitro </i>experimental data for acute exposure to <sup>60</sup>Co γ-rays, thermal neutrons, and BNCT with <sup>10</sup>B concentrations of 10 ppm. This indicates that microdosimetric quantities are important parameters for predicting dose-response curves for cell survival under BNCT irradiations. Furthermore, the model estimation at the endpoint of the mean activation dose exhibits a reduced impact of cell recovery during BNCT irradiations with high linear energy transfer (LET) compared to <sup>60</sup>Co γ-rays irradiation with low LET. Throughout this study, we discuss the advantages of BNCT for enhancing the killing of cancer cells with a reduced dose-rate dependency. If the neutron spectrum and the timelines for drug and dose delivery are provided, the present model will make it possible to predict radiosensitivity for more realistic dose-delivery schemes in BNCT irradiations.https://www.mdpi.com/2073-4409/9/5/1117boron neutron capture therapy (BNCT)microdosimetrydose-rate effects |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yusuke Matsuya Hisanori Fukunaga Motoko Omura Hiroyuki Date |
spellingShingle |
Yusuke Matsuya Hisanori Fukunaga Motoko Omura Hiroyuki Date A Model for Estimating Dose-Rate Effects on Cell-Killing of Human Melanoma after Boron Neutron Capture Therapy Cells boron neutron capture therapy (BNCT) microdosimetry dose-rate effects |
author_facet |
Yusuke Matsuya Hisanori Fukunaga Motoko Omura Hiroyuki Date |
author_sort |
Yusuke Matsuya |
title |
A Model for Estimating Dose-Rate Effects on Cell-Killing of Human Melanoma after Boron Neutron Capture Therapy |
title_short |
A Model for Estimating Dose-Rate Effects on Cell-Killing of Human Melanoma after Boron Neutron Capture Therapy |
title_full |
A Model for Estimating Dose-Rate Effects on Cell-Killing of Human Melanoma after Boron Neutron Capture Therapy |
title_fullStr |
A Model for Estimating Dose-Rate Effects on Cell-Killing of Human Melanoma after Boron Neutron Capture Therapy |
title_full_unstemmed |
A Model for Estimating Dose-Rate Effects on Cell-Killing of Human Melanoma after Boron Neutron Capture Therapy |
title_sort |
model for estimating dose-rate effects on cell-killing of human melanoma after boron neutron capture therapy |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2020-04-01 |
description |
Boron neutron capture therapy (BNCT) is a type of radiation therapy for eradicating tumor cells through a <sup>10</sup>B(n,α)<sup>7</sup>Li reaction in the presence of <sup>10</sup>B in cancer cells. When delivering a high absorbed dose to cancer cells using BNCT, both the timeline of <sup>10</sup>B concentrations and the relative long dose-delivery time compared to photon therapy must be considered. Changes in radiosensitivity during such a long dose-delivery time can reduce the probability of tumor control; however, such changes have not yet been evaluated. Here, we propose an improved <i>integrated microdosimetric-kinetic model </i>that accounts for changes in microdosimetric quantities and dose rates depending on the <sup>10</sup>B concentration and investigate the cell recovery (dose-rate effects) of melanoma during BNCT irradiation. The integrated microdosimetric–kinetic model used in this study considers both sub-lethal damage repair and changes in microdosimetric quantities during irradiation. The model, coupled with the Monte Carlo track structure simulation code of the Particle and Heavy Ion Transport code System, shows good agreement with <i>in vitro </i>experimental data for acute exposure to <sup>60</sup>Co γ-rays, thermal neutrons, and BNCT with <sup>10</sup>B concentrations of 10 ppm. This indicates that microdosimetric quantities are important parameters for predicting dose-response curves for cell survival under BNCT irradiations. Furthermore, the model estimation at the endpoint of the mean activation dose exhibits a reduced impact of cell recovery during BNCT irradiations with high linear energy transfer (LET) compared to <sup>60</sup>Co γ-rays irradiation with low LET. Throughout this study, we discuss the advantages of BNCT for enhancing the killing of cancer cells with a reduced dose-rate dependency. If the neutron spectrum and the timelines for drug and dose delivery are provided, the present model will make it possible to predict radiosensitivity for more realistic dose-delivery schemes in BNCT irradiations. |
topic |
boron neutron capture therapy (BNCT) microdosimetry dose-rate effects |
url |
https://www.mdpi.com/2073-4409/9/5/1117 |
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