Recombinant bovine alkaline fibroblast growth factor eye drops combined with sodium hyaluronate on dry eyes

• Main Authors: Xin Chen, Ye-Yu Shen
• Format: Article
• Language: English
• Published: Press of International Journal of Ophthalmology (IJO PRESS) 2019-02-01
• Series: Guoji Yanke Zazhi
• Subjects: cataract; recombinant bovine alkaline fibroblast growth factor eye drops; sodium hyaluronate; oxidative stress; inflammatory cytokines
• Online Access: http://ies.ijo.cn/cn_publish/2019/2/201902022.pdf

AIM: To explore the effect of recombinant bovine alkaline fibroblast growth factor eye drops combined with sodium hyaluronate on tear oxidative stress index, TNF-mutation and IL-6 levels in dry eye patients after phacoemulsification.<p>METHODS: From February 2016 to February 2018, 112 patients(172 eyes)of dry eyes were selected as the research objects. According to the law of random numbers, they were divided into two groups, each group with 86 eyes, and the control group was given sodium hyaluronate treatment, while the observation group was given recombinant bovine alkaline fibroblast growth factor eye drops combined with sodium hyaluronate. The efficacy, ocular surface, tear function, oxidative stress and inflammatory factors in tears were compared between the two groups.<p>RESULTS: After 4wk of treatment, the total effective rate of the observation group was 96.5%, which was significantly higher than that of the control group(<i>P</i>=0.001). Two groups of patients with preoperative fluorescent scores(FL), tear break-up time(BUT)and Schirmer Ⅰ test(SⅠt)had no statistical significance(<i>P</i>>0.05), postoperative medication, two groups of patients of FL were significantly decreased, which in the postoperative treatment, 4d, 8d and 28d, observation group decreased more obvious than control group. The repeatability of variance analysis results showed statistically significant differences between the two groups at different time points(<i>P</i><0.05). Postoperative drug treatment, BUT and SⅠt in the two groups were significantly increased especially on the 4d, 8d and 28d, observation group increased more obvious than control group. Repeated variance analysis results showed statistically significant differences between the two groups at different time points(<i>P</i><0.05). Two groups of patients before treatment in tears oxidative stress indicators malondialdehyde(MDA), lipid peroxide(LPO), superoxide disproportionation enzyme(SOD)and total antioxidant capacity(TAC)had no statistical significance(<i>P</i>>0.05), two groups of patients after treatment of oxidative stress indicators were significantly improved(<i>P</i><0.05), MDA and LPO of observation group were obviously lower than the control group(<i>P</i><0.05), SOD and TAC were significantly higher than control group(<i>P</i><0.05). Before the treatment, there was no statistically significant difference between the two groups in terms of TNF-α and IL-6 in their tears(<i>P</i>>0.05). After the treatment, TNF-α and IL-6 in the tears of the two groups decreased significantly(<i>P</i><0.05), and the decrease was more significant in the observation group than the control group(<i>P</i><0.05).<p>CONCLUSION: Recombinant bovine alkaline fibroblast growth factor eye drops combined with sodium hyaluronate have significant effects on dry eyes after phacoemulsification of cataract, which cannot only promote the stability of tear film, but also reduce tear secretion and corneal injury. The effect may be related to the improvement of oxidative stress index and the regulation of inflammatory factors.