| Summary: | Objective To investigate the influencing factors of cerebral oxygen supply-consumption balance and cerebral autoregulation (CA) under propofol anesthesia. Methods A total of 66 patients undergoing open abdominal surgery with propofol anesthesia in our hospital from August 2019 to January 2020 were prospectively recruited in this study. Their general information was collected. Regional cerebral oxygen saturation (rSO2), cerebral tissue hemoglobin concentration index (THI), mean arterial pressure (MAP), arterial blood gas indexes, and cardiac index (CI) were collected real-timely from entering the operating room to the end of the operation. Then Pearson correlation coefficients of rSO2 and MAP were calculated for cerebral oximetry index (COx), and the coefficients of THI and MAP were obtained for cerebral total hemoglobin reactivity index (THx) in order to find out the upper and lower limits of CA range. Univariate analysis and multivariate linear regression analysis were used to analyze the general data, intraoperative monitoring data and blood gas indexes to screen out the influencing factors for rSO2, THI, and the upper and lower limits of the CA range defined by COx and THx. Results After elimination of confounding factors by univariate analysis, multivariate linear regression analysis showed that the influencing factors of rSO2 included operation time and total hemoglobin concentration (P<0.05), that of THI was age (P<0.05), and those for the upper and lower limits of CA obtained by COx included the history of hypertension (P<0.05), intraoperative MAP (P<0.05), and PaO2 (P<0.05). The influencing factors of the upper and lower limits of CA obtained by THx included the history of hypertension (P<0.05) and intraoperative MAP (P<0.05). Conclusion Age, total hemoglobin concentration, and operation duration are the influencing factors of the balance of cerebral oxygen supply and demand in the patients under propofol anesthesia, and the history of hypertension, intraoperative MAP, PaO2, are the influencing factors of cerebral blood flow autoregulation.
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