Similar environments but diverse fates: Responses of budding yeast to nutrient deprivation.
Diploid budding yeast (Saccharomyces cerevisiae) can adopt one of several alternative differentiation fates in response to nutrient limitation, and each of these fates provides distinct biological functions. When different strain backgrounds are taken into account, these various fates occur in respo...
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doaj-a2c6942ed7c941b191ccd73316caa0c02020-11-24T22:32:32ZengShared Science Publishers OGMicrobial Cell2311-26382016-08-013830232810.15698/mic2016.08.516Similar environments but diverse fates: Responses of budding yeast to nutrient deprivation.Saul M. Honigberg0Division of Cell Biology and Biophysics, University of Missouri-Kansas City, 5007 Rockhill Rd, Kansas City MO 64110, USA.Diploid budding yeast (Saccharomyces cerevisiae) can adopt one of several alternative differentiation fates in response to nutrient limitation, and each of these fates provides distinct biological functions. When different strain backgrounds are taken into account, these various fates occur in response to similar environmental cues, are regulated by the same signal transduction pathways, and share many of the same master regulators. I propose that the relationships between fate choice, environmental cues and signaling pathways are not Boolean, but involve graded levels of signals, pathway activation and master-regulator activity. In the absence of large differences between environmental cues, small differences in the concentration of cues may be reinforced by cell-to-cell signals. These signals are particularly essential for fate determination within communities, such as colonies and biofilms, where fate choice varies dramatically from one region of the community to another. The lack of Boolean relationships between cues, signaling pathways, master regulators and cell fates may allow yeast communities to respond appropriately to the wide range of environments they encounter in nature.http://microbialcell.com/researcharticles/similar-environments-but-diverse-fates-responses-of-budding-yeast-to-nutrient-deprivation/pseudohyphal growthsporulation meiosisquiescenceBoolean logiccell-cell signalsyeast communities |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Saul M. Honigberg |
spellingShingle |
Saul M. Honigberg Similar environments but diverse fates: Responses of budding yeast to nutrient deprivation. Microbial Cell pseudohyphal growth sporulation meiosis quiescence Boolean logic cell-cell signals yeast communities |
author_facet |
Saul M. Honigberg |
author_sort |
Saul M. Honigberg |
title |
Similar environments but diverse fates: Responses of budding yeast to nutrient deprivation. |
title_short |
Similar environments but diverse fates: Responses of budding yeast to nutrient deprivation. |
title_full |
Similar environments but diverse fates: Responses of budding yeast to nutrient deprivation. |
title_fullStr |
Similar environments but diverse fates: Responses of budding yeast to nutrient deprivation. |
title_full_unstemmed |
Similar environments but diverse fates: Responses of budding yeast to nutrient deprivation. |
title_sort |
similar environments but diverse fates: responses of budding yeast to nutrient deprivation. |
publisher |
Shared Science Publishers OG |
series |
Microbial Cell |
issn |
2311-2638 |
publishDate |
2016-08-01 |
description |
Diploid budding yeast (Saccharomyces cerevisiae) can adopt one of several alternative differentiation fates in response to nutrient limitation, and each of these fates provides distinct biological functions. When different strain backgrounds are taken into account, these various fates occur in response to similar environmental cues, are regulated by the same signal transduction pathways, and share many of the same master regulators. I propose that the relationships between fate choice, environmental cues and signaling pathways are not Boolean, but involve graded levels of signals, pathway activation and master-regulator activity. In the absence of large differences between environmental cues, small differences in the concentration of cues may be reinforced by cell-to-cell signals. These signals are particularly essential for fate determination within communities, such as colonies and biofilms, where fate choice varies dramatically from one region of the community to another. The lack of Boolean relationships between cues, signaling pathways, master regulators and cell fates may allow yeast communities to respond appropriately to the wide range of environments they encounter in nature. |
topic |
pseudohyphal growth sporulation meiosis quiescence Boolean logic cell-cell signals yeast communities |
url |
http://microbialcell.com/researcharticles/similar-environments-but-diverse-fates-responses-of-budding-yeast-to-nutrient-deprivation/ |
work_keys_str_mv |
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