Endoplasmic reticulum stress response in yeast and humans

Endoplasmic reticulum stress response in yeast and humans

Stress pathways monitor intracellular systems and deploy a range of regulatory mechanisms in response to stress. One of the best-characterized pathways, the UPR (unfolded protein response), is an intracellular signal transduction pathway that monitors ER (endoplasmic reticulum) homoeostasis. Its ac...

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Bibliographic Details
Main Authors: Haoxi Wu, Benjamin S. H. Ng, Guillaume Thibault
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2014-07-01
Series:Bioscience Reports
Subjects:
ER stress
IRE1
lipid disequilibrium
protein homoeostasis
unfolded protein response
UPR-related diseases. The UPR (unfolded protein response) is activated to alleviate the effects of ER (endoplasmic reticulum) stress and is highly conserved from yeast to human. In this review
we summarize the major advances in yeast and humans
Online Access:http://www.bioscirep.org/bsr/034/e118/bsr034e118.htm

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