Leanness and Low Plasma Leptin in GPR17 Knockout Mice Are Dependent on Strain and Associated With Increased Energy Intake That Is Not Suppressed by Exogenous Leptin

Leanness and Low Plasma Leptin in GPR17 Knockout Mice Are Dependent on Strain and Associated With Increased Energy Intake That Is Not Suppressed by Exogenous Leptin

Previous studies have shown that agonists of GPR17 stimulate, while antagonists inhibit feeding. However, whole body knockout of GPR17 in mice of the C57Bl/6 strain did not affect energy balance, whereas selective knockout in oligodendrocytes or pro-opiomelanocortin neurons provided protection from...

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Bibliographic Details
Main Authors: Edward T. Wargent, Suhaib J. S. Ahmad, Qing Richard Lu, Evi Kostenis, Jonathan R. S. Arch, Claire J. Stocker
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Endocrinology
Subjects:
GPR 17 knockout mouse
genetic background
high fat diet
body composition
leptin resistance
energy expenditure
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.698115/full

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