Generation of two non-integrated induced pluripotent stem cell lines from urine-derived cells of a Chinese patient carrying NF1 gene mutation
Mutations in the neurofibromin (NF1) gene cause neurofibromatosis type 1 (NF1), a complex tumour predisposition syndrome. Here, we generated two induced pluripotent stem cell (iPSC) lines using urine cells (UCs) derived from a 21-year-old female NF1 patient carrying c.496_497delGT mutation in the NF...
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doaj-a2d869ce967849498abfd70ed026b5b12020-11-25T03:07:30ZengElsevierStem Cell Research1873-50612020-07-0146101842Generation of two non-integrated induced pluripotent stem cell lines from urine-derived cells of a Chinese patient carrying NF1 gene mutationLiang Shi0Yazhou Cui1Zijuan Qi2Xiaoyan Zhou3Jing Luan4Jinxiang Han5Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan 250014, Shandong, China; Biomedical Sciences College, Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan 250062, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, Ji’nan 250062, Shandong, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, Ji’nan 250062, Shandong, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan 250014, Shandong, China; Biomedical Sciences College, Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan 250062, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, Ji’nan 250062, Shandong, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, Ji’nan 250062, Shandong, ChinaBiomedical Sciences College, Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan 250062, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, Ji’nan 250062, Shandong, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, Ji’nan 250062, Shandong, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan 250014, Shandong, China; Biomedical Sciences College, Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan 250062, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, Ji’nan 250062, Shandong, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, Ji’nan 250062, Shandong, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan 250014, Shandong, China; Biomedical Sciences College, Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan 250062, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, Ji’nan 250062, Shandong, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, Ji’nan 250062, Shandong, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan 250014, Shandong, China; Biomedical Sciences College, Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan 250062, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, Ji’nan 250062, Shandong, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, Ji’nan 250062, Shandong, China; Corresponding author at: Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji'nan, Shandong, China.Mutations in the neurofibromin (NF1) gene cause neurofibromatosis type 1 (NF1), a complex tumour predisposition syndrome. Here, we generated two induced pluripotent stem cell (iPSC) lines using urine cells (UCs) derived from a 21-year-old female NF1 patient carrying c.496_497delGT mutation in the NF1 gene (p.Val166LeufsTer7). The newly derived SMBCi003-A and SMBCi003-B iPSC lines used as a cellular model to unravel pathogenesis of NF1.http://www.sciencedirect.com/science/article/pii/S1873506120301434 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Liang Shi Yazhou Cui Zijuan Qi Xiaoyan Zhou Jing Luan Jinxiang Han |
spellingShingle |
Liang Shi Yazhou Cui Zijuan Qi Xiaoyan Zhou Jing Luan Jinxiang Han Generation of two non-integrated induced pluripotent stem cell lines from urine-derived cells of a Chinese patient carrying NF1 gene mutation Stem Cell Research |
author_facet |
Liang Shi Yazhou Cui Zijuan Qi Xiaoyan Zhou Jing Luan Jinxiang Han |
author_sort |
Liang Shi |
title |
Generation of two non-integrated induced pluripotent stem cell lines from urine-derived cells of a Chinese patient carrying NF1 gene mutation |
title_short |
Generation of two non-integrated induced pluripotent stem cell lines from urine-derived cells of a Chinese patient carrying NF1 gene mutation |
title_full |
Generation of two non-integrated induced pluripotent stem cell lines from urine-derived cells of a Chinese patient carrying NF1 gene mutation |
title_fullStr |
Generation of two non-integrated induced pluripotent stem cell lines from urine-derived cells of a Chinese patient carrying NF1 gene mutation |
title_full_unstemmed |
Generation of two non-integrated induced pluripotent stem cell lines from urine-derived cells of a Chinese patient carrying NF1 gene mutation |
title_sort |
generation of two non-integrated induced pluripotent stem cell lines from urine-derived cells of a chinese patient carrying nf1 gene mutation |
publisher |
Elsevier |
series |
Stem Cell Research |
issn |
1873-5061 |
publishDate |
2020-07-01 |
description |
Mutations in the neurofibromin (NF1) gene cause neurofibromatosis type 1 (NF1), a complex tumour predisposition syndrome. Here, we generated two induced pluripotent stem cell (iPSC) lines using urine cells (UCs) derived from a 21-year-old female NF1 patient carrying c.496_497delGT mutation in the NF1 gene (p.Val166LeufsTer7). The newly derived SMBCi003-A and SMBCi003-B iPSC lines used as a cellular model to unravel pathogenesis of NF1. |
url |
http://www.sciencedirect.com/science/article/pii/S1873506120301434 |
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