Generation of two non-integrated induced pluripotent stem cell lines from urine-derived cells of a Chinese patient carrying NF1 gene mutation

Mutations in the neurofibromin (NF1) gene cause neurofibromatosis type 1 (NF1), a complex tumour predisposition syndrome. Here, we generated two induced pluripotent stem cell (iPSC) lines using urine cells (UCs) derived from a 21-year-old female NF1 patient carrying c.496_497delGT mutation in the NF...

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Main Authors:	Liang Shi, Yazhou Cui, Zijuan Qi, Xiaoyan Zhou, Jing Luan, Jinxiang Han
Format:	Article
Language:	English
Published:	Elsevier 2020-07-01
Series:	Stem Cell Research
Online Access:	http://www.sciencedirect.com/science/article/pii/S1873506120301434

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spelling	doaj-a2d869ce967849498abfd70ed026b5b12020-11-25T03:07:30ZengElsevierStem Cell Research1873-50612020-07-0146101842Generation of two non-integrated induced pluripotent stem cell lines from urine-derived cells of a Chinese patient carrying NF1 gene mutationLiang Shi0Yazhou Cui1Zijuan Qi2Xiaoyan Zhou3Jing Luan4Jinxiang Han5Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan 250014, Shandong, China; Biomedical Sciences College, Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan 250062, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, Ji’nan 250062, Shandong, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, Ji’nan 250062, Shandong, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan 250014, Shandong, China; Biomedical Sciences College, Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan 250062, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, Ji’nan 250062, Shandong, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, Ji’nan 250062, Shandong, ChinaBiomedical Sciences College, Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan 250062, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, Ji’nan 250062, Shandong, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, Ji’nan 250062, Shandong, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan 250014, Shandong, China; Biomedical Sciences College, Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan 250062, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, Ji’nan 250062, Shandong, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, Ji’nan 250062, Shandong, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan 250014, Shandong, China; Biomedical Sciences College, Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan 250062, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, Ji’nan 250062, Shandong, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, Ji’nan 250062, Shandong, ChinaDepartment of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan 250014, Shandong, China; Biomedical Sciences College, Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan 250062, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, Ji’nan 250062, Shandong, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, Ji’nan 250062, Shandong, China; Corresponding author at: Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji'nan, Shandong, China.Mutations in the neurofibromin (NF1) gene cause neurofibromatosis type 1 (NF1), a complex tumour predisposition syndrome. Here, we generated two induced pluripotent stem cell (iPSC) lines using urine cells (UCs) derived from a 21-year-old female NF1 patient carrying c.496_497delGT mutation in the NF1 gene (p.Val166LeufsTer7). The newly derived SMBCi003-A and SMBCi003-B iPSC lines used as a cellular model to unravel pathogenesis of NF1.http://www.sciencedirect.com/science/article/pii/S1873506120301434
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Liang Shi Yazhou Cui Zijuan Qi Xiaoyan Zhou Jing Luan Jinxiang Han
spellingShingle	Liang Shi Yazhou Cui Zijuan Qi Xiaoyan Zhou Jing Luan Jinxiang Han Generation of two non-integrated induced pluripotent stem cell lines from urine-derived cells of a Chinese patient carrying NF1 gene mutation Stem Cell Research
author_facet	Liang Shi Yazhou Cui Zijuan Qi Xiaoyan Zhou Jing Luan Jinxiang Han
author_sort	Liang Shi
title	Generation of two non-integrated induced pluripotent stem cell lines from urine-derived cells of a Chinese patient carrying NF1 gene mutation
title_short	Generation of two non-integrated induced pluripotent stem cell lines from urine-derived cells of a Chinese patient carrying NF1 gene mutation
title_full	Generation of two non-integrated induced pluripotent stem cell lines from urine-derived cells of a Chinese patient carrying NF1 gene mutation
title_fullStr	Generation of two non-integrated induced pluripotent stem cell lines from urine-derived cells of a Chinese patient carrying NF1 gene mutation
title_full_unstemmed	Generation of two non-integrated induced pluripotent stem cell lines from urine-derived cells of a Chinese patient carrying NF1 gene mutation
title_sort	generation of two non-integrated induced pluripotent stem cell lines from urine-derived cells of a chinese patient carrying nf1 gene mutation
publisher	Elsevier
series	Stem Cell Research
issn	1873-5061
publishDate	2020-07-01
description	Mutations in the neurofibromin (NF1) gene cause neurofibromatosis type 1 (NF1), a complex tumour predisposition syndrome. Here, we generated two induced pluripotent stem cell (iPSC) lines using urine cells (UCs) derived from a 21-year-old female NF1 patient carrying c.496_497delGT mutation in the NF1 gene (p.Val166LeufsTer7). The newly derived SMBCi003-A and SMBCi003-B iPSC lines used as a cellular model to unravel pathogenesis of NF1.
url	http://www.sciencedirect.com/science/article/pii/S1873506120301434
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Generation of two non-integrated induced pluripotent stem cell lines from urine-derived cells of a Chinese patient carrying NF1 gene mutation

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