Sesquiterpenoids and Their Anti-Inflammatory Activity: Evaluation of Ainsliaea yunnanensis

Four new sesquiterpenoids (1−4) and six known sesquiterpenoids (5−10), were isolated from the EtOAc phase of the ethanolic extract of Ainsliaea yunnanensis. Their structures were establ...

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Main Authors:	Jinjie Li, Xiuting Li, Xin Wang, Xiangjian Zhong, Linlin Ji, Zihan Guo, Yiran Liu, Xiaoya Shang
Format:	Article
Language:	English
Published:	MDPI AG 2019-05-01
Series:	Molecules
Subjects:	<i>Ainsliaea yunnanensis</i> sesquiterpenoids structures inflammasome
Online Access:	https://www.mdpi.com/1420-3049/24/9/1701

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spelling	doaj-a2e2a87665aa4a3eb5570743a69319812020-11-25T01:05:48ZengMDPI AGMolecules1420-30492019-05-01249170110.3390/molecules24091701molecules24091701Sesquiterpenoids and Their Anti-Inflammatory Activity: Evaluation of <i>Ainsliaea yunnanensis</i>Jinjie Li0Xiuting Li1Xin Wang2Xiangjian Zhong3Linlin Ji4Zihan Guo5Yiran Liu6Xiaoya Shang7Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, ChinaBeijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, ChinaBeijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, ChinaBeijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, ChinaBeijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, ChinaBeijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, ChinaBeijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, ChinaFour new sesquiterpenoids (<b>1</b>−<b>4</b>) and six known sesquiterpenoids (<b>5</b>−<b>10</b>), were isolated from the EtOAc phase of the ethanolic extract of <i>Ainsliaea yunnanensis</i>. Their structures were established by spectroscopic methods, including 1-D, 2-D NMR and HPLC-MS. All compounds were tested for their anti-inflammatory effect by the inhibition of the activity of NLRP3 inflammasome by blocking the self-slicing of pro-caspase-1, which is induced by nigericin, then the secretion of mature IL-1β, mediated by caspase-1, was suppressed. Unfortunately none of the compounds showed an anti-inflammatory effect.https://www.mdpi.com/1420-3049/24/9/1701<i>Ainsliaea yunnanensis</i>sesquiterpenoidsstructuresinflammasome
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jinjie Li Xiuting Li Xin Wang Xiangjian Zhong Linlin Ji Zihan Guo Yiran Liu Xiaoya Shang
spellingShingle	Jinjie Li Xiuting Li Xin Wang Xiangjian Zhong Linlin Ji Zihan Guo Yiran Liu Xiaoya Shang Sesquiterpenoids and Their Anti-Inflammatory Activity: Evaluation of <i>Ainsliaea yunnanensis</i> Molecules <i>Ainsliaea yunnanensis</i> sesquiterpenoids structures inflammasome
author_facet	Jinjie Li Xiuting Li Xin Wang Xiangjian Zhong Linlin Ji Zihan Guo Yiran Liu Xiaoya Shang
author_sort	Jinjie Li
title	Sesquiterpenoids and Their Anti-Inflammatory Activity: Evaluation of <i>Ainsliaea yunnanensis</i>
title_short	Sesquiterpenoids and Their Anti-Inflammatory Activity: Evaluation of <i>Ainsliaea yunnanensis</i>
title_full	Sesquiterpenoids and Their Anti-Inflammatory Activity: Evaluation of <i>Ainsliaea yunnanensis</i>
title_fullStr	Sesquiterpenoids and Their Anti-Inflammatory Activity: Evaluation of <i>Ainsliaea yunnanensis</i>
title_full_unstemmed	Sesquiterpenoids and Their Anti-Inflammatory Activity: Evaluation of <i>Ainsliaea yunnanensis</i>
title_sort	sesquiterpenoids and their anti-inflammatory activity: evaluation of <i>ainsliaea yunnanensis</i>
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2019-05-01
description	Four new sesquiterpenoids (<b>1</b>−<b>4</b>) and six known sesquiterpenoids (<b>5</b>−<b>10</b>), were isolated from the EtOAc phase of the ethanolic extract of <i>Ainsliaea yunnanensis</i>. Their structures were established by spectroscopic methods, including 1-D, 2-D NMR and HPLC-MS. All compounds were tested for their anti-inflammatory effect by the inhibition of the activity of NLRP3 inflammasome by blocking the self-slicing of pro-caspase-1, which is induced by nigericin, then the secretion of mature IL-1β, mediated by caspase-1, was suppressed. Unfortunately none of the compounds showed an anti-inflammatory effect.
topic	<i>Ainsliaea yunnanensis</i> sesquiterpenoids structures inflammasome
url	https://www.mdpi.com/1420-3049/24/9/1701
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Sesquiterpenoids and Their Anti-Inflammatory Activity: Evaluation of <i>Ainsliaea yunnanensis</i>

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