Association of psoriasis with asthma: A systematic review and meta-analysis of observational studies
Background: Psoriasis is a chronic inflammatory skin disease that has been associated with various inflammatory comorbidities such as cardiovascular disease and uveitis. Asthma involves inflammation of the airway. The two diseases share cytokine-mediated inflammatory mechanisms. Objectives: The main...
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Wolters Kluwer Medknow Publications
2020-01-01
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doaj-a2e68a2f2911476883591b3692ef07352020-11-25T01:29:14ZengWolters Kluwer Medknow PublicationsDermatologica Sinica1027-81172223-330X2020-01-01381222710.4103/ds.ds_33_19Association of psoriasis with asthma: A systematic review and meta-analysis of observational studiesTien-Pei FangYu-Ching LinChing-Chi ChiBackground: Psoriasis is a chronic inflammatory skin disease that has been associated with various inflammatory comorbidities such as cardiovascular disease and uveitis. Asthma involves inflammation of the airway. The two diseases share cytokine-mediated inflammatory mechanisms. Objectives: The main objective of the study was to examine the association of psoriasis with asthma. Methods: We conducted a systematic review and meta-analysis of observational studies that examined the association of psoriasis with asthma. We searched MEDLINE, Embase, and CENTRAL from inception to May 2, 2019 for relevant case–control, cross-sectional, or cohort studies. The risk of bias of included studies was assessed by using the Newcastle–Ottawa Scale. The random-effects model meta-analysis was used to calculate the odds ratio (OR) for case–control/cross-sectional studies and hazard ratio (HR) for cohort studies. Results: We included six case–control/cross-sectional (one case–control and five cross-sectional studies) and one cohort studies. Three studies were rated with a high risk of bias in case definition, representativeness of the cases, selection of controls, definition of controls, and ascertainment of exposure. Psoriasis was associated with significantly increased odds (OR 1.29; 95% confidence interval [CI] 1.20-'1.37) and risk (HR 1.38; 95% CI 1.23-'1.54) for asthma. A subgroup analysis revealed increased odds for asthma in both pediatric and adult patients with psoriasis (pooled OR being 1.24 [95% CI 1.10-'1.41] and OR 1.38 [95% CI 1.27-'1.50], respectively). Conclusion: The current evidence indicates a significant association of psoriasis with asthma. When psoriasis patients present with respiratory symptoms for shortness of breath, wheezing, and chest tightness, referral to pulmonologist may be considered.http://www.dermsinica.org/article.asp?issn=1027-8117;year=2020;volume=38;issue=1;spage=22;epage=27;aulast=Fangasthmameta-analysispsoriasissystematic review |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tien-Pei Fang Yu-Ching Lin Ching-Chi Chi |
spellingShingle |
Tien-Pei Fang Yu-Ching Lin Ching-Chi Chi Association of psoriasis with asthma: A systematic review and meta-analysis of observational studies Dermatologica Sinica asthma meta-analysis psoriasis systematic review |
author_facet |
Tien-Pei Fang Yu-Ching Lin Ching-Chi Chi |
author_sort |
Tien-Pei Fang |
title |
Association of psoriasis with asthma: A systematic review and meta-analysis of observational studies |
title_short |
Association of psoriasis with asthma: A systematic review and meta-analysis of observational studies |
title_full |
Association of psoriasis with asthma: A systematic review and meta-analysis of observational studies |
title_fullStr |
Association of psoriasis with asthma: A systematic review and meta-analysis of observational studies |
title_full_unstemmed |
Association of psoriasis with asthma: A systematic review and meta-analysis of observational studies |
title_sort |
association of psoriasis with asthma: a systematic review and meta-analysis of observational studies |
publisher |
Wolters Kluwer Medknow Publications |
series |
Dermatologica Sinica |
issn |
1027-8117 2223-330X |
publishDate |
2020-01-01 |
description |
Background: Psoriasis is a chronic inflammatory skin disease that has been associated with various inflammatory comorbidities such as cardiovascular disease and uveitis. Asthma involves inflammation of the airway. The two diseases share cytokine-mediated inflammatory mechanisms. Objectives: The main objective of the study was to examine the association of psoriasis with asthma. Methods: We conducted a systematic review and meta-analysis of observational studies that examined the association of psoriasis with asthma. We searched MEDLINE, Embase, and CENTRAL from inception to May 2, 2019 for relevant case–control, cross-sectional, or cohort studies. The risk of bias of included studies was assessed by using the Newcastle–Ottawa Scale. The random-effects model meta-analysis was used to calculate the odds ratio (OR) for case–control/cross-sectional studies and hazard ratio (HR) for cohort studies. Results: We included six case–control/cross-sectional (one case–control and five cross-sectional studies) and one cohort studies. Three studies were rated with a high risk of bias in case definition, representativeness of the cases, selection of controls, definition of controls, and ascertainment of exposure. Psoriasis was associated with significantly increased odds (OR 1.29; 95% confidence interval [CI] 1.20-'1.37) and risk (HR 1.38; 95% CI 1.23-'1.54) for asthma. A subgroup analysis revealed increased odds for asthma in both pediatric and adult patients with psoriasis (pooled OR being 1.24 [95% CI 1.10-'1.41] and OR 1.38 [95% CI 1.27-'1.50], respectively). Conclusion: The current evidence indicates a significant association of psoriasis with asthma. When psoriasis patients present with respiratory symptoms for shortness of breath, wheezing, and chest tightness, referral to pulmonologist may be considered. |
topic |
asthma meta-analysis psoriasis systematic review |
url |
http://www.dermsinica.org/article.asp?issn=1027-8117;year=2020;volume=38;issue=1;spage=22;epage=27;aulast=Fang |
work_keys_str_mv |
AT tienpeifang associationofpsoriasiswithasthmaasystematicreviewandmetaanalysisofobservationalstudies AT yuchinglin associationofpsoriasiswithasthmaasystematicreviewandmetaanalysisofobservationalstudies AT chingchichi associationofpsoriasiswithasthmaasystematicreviewandmetaanalysisofobservationalstudies |
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1725097591429922816 |