The Potential Role of Human Papillomavirus Infection in Bell's Palsy: A Hypothesis-Generating Study Based on a Nationwide Cohort
Objective: Our purpose was to investigate whether people with a previous human papillomavirus (HPV) infection were associated with an increased risk of Bell's palsy (BP).Methods: By using Taiwan population-based data, patients aged > 18 years with HPV infection (n = 22,260) from 2000 to...
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Frontiers Media S.A.
2021-09-01
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doaj-a2e6f79cc03547e7a8e5b1597608ae722021-09-04T11:11:08ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-09-01810.3389/fmed.2021.616873616873The Potential Role of Human Papillomavirus Infection in Bell's Palsy: A Hypothesis-Generating Study Based on a Nationwide CohortKuan-Ying Li0Kuan-Ying Li1Kuan-Ying Li2Mei-Chia Chou3Mei-Chia Chou4Mei-Chia Chou5Mei-Chia Chou6Renin Chang7Renin Chang8Hei-Tung Yip9Hei-Tung Yip10Hei-Tung Yip11Yao-Min Hung12Yao-Min Hung13Yao-Min Hung14Yao-Min Hung15James Cheng-Chung Wei16James Cheng-Chung Wei17James Cheng-Chung Wei18Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanDepartment of Neurology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanNeuroscience Research Center, Kaohsiung Medical University, Kaohsiung, TaiwanShu-Zen Junior College of Medicine and Management, Kaohsiung, TaiwanDepartment of Recreation and Sports Management, Tajen University, Pingtung, TaiwanDepartment of Physical Medicine and Rehabilitation, Kaohsiung Veterans General Hospital, Pingtung, TaiwanGraduate Institute of Bioresources, National Pingtung University of Science and Technology, Pingtung, TaiwanDepartment of Emergency Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan0Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan1College of Medicine, China Medical University, Taichung, Taiwan2Institute of Public Health (Biostatistics), National Yangming University, Taipei, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan3Department of Internal Medicine, Kaohsiung Municipal United Hospital, Kaohsiung, Taiwan4College of Health and Nursing, Meiho University, Pingung, Taiwan5National Yang-Ming University, School of Medicine, Taipei, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan6Division of Allergy, Immunology and Rheumatology, Chung Shan Medical University Hospital, Taichung, Taiwan7Graduate Institute of Integrated Medicine, China Medical University, Taichung, TaiwanObjective: Our purpose was to investigate whether people with a previous human papillomavirus (HPV) infection were associated with an increased risk of Bell's palsy (BP).Methods: By using Taiwan population-based data, patients aged > 18 years with HPV infection (n = 22,260) from 2000 to 2012 were enrolled and compared with control subjects who had never been diagnosed with an HPV infection at a 1:4 ratio matched by sex, age, index date, and co-morbidities (n = 89,040). The index date was the first date of HPV diagnosis. All the patients were tracked until the occurrence of BP. Cox proportional hazards regression was applied to estimate the hazard ratios (HRs) for the development of BP in both groups.Results: The HPV group had 1.25 [95% confidence interval (CI) = 1.03–1.51] times higher risk of BP compared with the non-HPV group after adjusting for sex, age, and co-morbidities. The association of HPV and BP was significant in the sensitivity analyses. In the subgroup analysis, the impact of HPV infection on the risk of BP was more pronounced in the elderly > 50 years [adjusted hazard ratio (aHR) =1.86; 95% CI = 1.37–2.52], hypertension (aHR = 1.65; 95% CI = 1.17–2.31), and chronic obstructive pulmonary disease (aHR = 2.14, 95% CI 1.333.43) subgroups.Conclusions: Patients with HPV infection have a higher risk of subsequent BP compared with non-HPV patients. More rigorous studies are needed to confirm if and how specific HPV genotypes are associated with BP and the possible role of vaccines in disease prevention.https://www.frontiersin.org/articles/10.3389/fmed.2021.616873/fullBell's palsyhuman papillomaviruscohort studyinfectionHPV |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kuan-Ying Li Kuan-Ying Li Kuan-Ying Li Mei-Chia Chou Mei-Chia Chou Mei-Chia Chou Mei-Chia Chou Renin Chang Renin Chang Hei-Tung Yip Hei-Tung Yip Hei-Tung Yip Yao-Min Hung Yao-Min Hung Yao-Min Hung Yao-Min Hung James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei |
spellingShingle |
Kuan-Ying Li Kuan-Ying Li Kuan-Ying Li Mei-Chia Chou Mei-Chia Chou Mei-Chia Chou Mei-Chia Chou Renin Chang Renin Chang Hei-Tung Yip Hei-Tung Yip Hei-Tung Yip Yao-Min Hung Yao-Min Hung Yao-Min Hung Yao-Min Hung James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei The Potential Role of Human Papillomavirus Infection in Bell's Palsy: A Hypothesis-Generating Study Based on a Nationwide Cohort Frontiers in Medicine Bell's palsy human papillomavirus cohort study infection HPV |
author_facet |
Kuan-Ying Li Kuan-Ying Li Kuan-Ying Li Mei-Chia Chou Mei-Chia Chou Mei-Chia Chou Mei-Chia Chou Renin Chang Renin Chang Hei-Tung Yip Hei-Tung Yip Hei-Tung Yip Yao-Min Hung Yao-Min Hung Yao-Min Hung Yao-Min Hung James Cheng-Chung Wei James Cheng-Chung Wei James Cheng-Chung Wei |
author_sort |
Kuan-Ying Li |
title |
The Potential Role of Human Papillomavirus Infection in Bell's Palsy: A Hypothesis-Generating Study Based on a Nationwide Cohort |
title_short |
The Potential Role of Human Papillomavirus Infection in Bell's Palsy: A Hypothesis-Generating Study Based on a Nationwide Cohort |
title_full |
The Potential Role of Human Papillomavirus Infection in Bell's Palsy: A Hypothesis-Generating Study Based on a Nationwide Cohort |
title_fullStr |
The Potential Role of Human Papillomavirus Infection in Bell's Palsy: A Hypothesis-Generating Study Based on a Nationwide Cohort |
title_full_unstemmed |
The Potential Role of Human Papillomavirus Infection in Bell's Palsy: A Hypothesis-Generating Study Based on a Nationwide Cohort |
title_sort |
potential role of human papillomavirus infection in bell's palsy: a hypothesis-generating study based on a nationwide cohort |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Medicine |
issn |
2296-858X |
publishDate |
2021-09-01 |
description |
Objective: Our purpose was to investigate whether people with a previous human papillomavirus (HPV) infection were associated with an increased risk of Bell's palsy (BP).Methods: By using Taiwan population-based data, patients aged > 18 years with HPV infection (n = 22,260) from 2000 to 2012 were enrolled and compared with control subjects who had never been diagnosed with an HPV infection at a 1:4 ratio matched by sex, age, index date, and co-morbidities (n = 89,040). The index date was the first date of HPV diagnosis. All the patients were tracked until the occurrence of BP. Cox proportional hazards regression was applied to estimate the hazard ratios (HRs) for the development of BP in both groups.Results: The HPV group had 1.25 [95% confidence interval (CI) = 1.03–1.51] times higher risk of BP compared with the non-HPV group after adjusting for sex, age, and co-morbidities. The association of HPV and BP was significant in the sensitivity analyses. In the subgroup analysis, the impact of HPV infection on the risk of BP was more pronounced in the elderly > 50 years [adjusted hazard ratio (aHR) =1.86; 95% CI = 1.37–2.52], hypertension (aHR = 1.65; 95% CI = 1.17–2.31), and chronic obstructive pulmonary disease (aHR = 2.14, 95% CI 1.333.43) subgroups.Conclusions: Patients with HPV infection have a higher risk of subsequent BP compared with non-HPV patients. More rigorous studies are needed to confirm if and how specific HPV genotypes are associated with BP and the possible role of vaccines in disease prevention. |
topic |
Bell's palsy human papillomavirus cohort study infection HPV |
url |
https://www.frontiersin.org/articles/10.3389/fmed.2021.616873/full |
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