Association of genetic ancestry with colorectal tumor location in Puerto Rican Latinos
Abstract Background Colorectal cancer (CRC) is the first cause of cancer deaths among Puerto Ricans. The incidence and mortality of CRC in Puerto Rico continue to be on the rise. The burden of CRC in Puerto Rico is higher than among US Hispanics and is second only to African Americans, thus supporti...
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doaj-a2ea27cf9e674ecd8762bc87e490caf52020-11-25T02:06:21ZengBMCHuman Genomics1479-73642019-02-0113111110.1186/s40246-019-0196-4Association of genetic ancestry with colorectal tumor location in Puerto Rican LatinosJulyann Pérez-Mayoral0Marievelisse Soto-Salgado1Ebony Shah2Rick Kittles3Mariana C. Stern4Myrta I. Olivera5María Gonzalez-Pons6Segundo Rodriguez-Quilichinni7Marla Torres8Jose S. Reyes9Luis Tous10Nicolas López11Victor Carlo Chevere12Marcia Cruz-Correa13Division of Cancer Biology, University of Puerto Rico Comprehensive Cancer CenterDepartment of Biochemistry, University of Puerto Rico Medical Sciences CampusDepartment of Surgery, Division of Urology, University of Arizona College of MedicineDepartment of Population Sciences, Division of Health Equities, City of Hope Comprehensive CenterDepartment of Preventive Medicine and Urology, Norris Comprehensive Cancer Center, Keck School of Medicine of USCDivision of Cancer Biology, University of Puerto Rico Comprehensive Cancer CenterDivision of Cancer Biology, University of Puerto Rico Comprehensive Cancer CenterDepartment of Biochemistry and Medicine, School of Medicine, University of Puerto Rico Medical Sciences CampusColorectal Surgery Clinic, Ashford Presbyterian HospitalColorectal Surgery Clinic, Ashford Presbyterian HospitalColorectal Surgery Clinic, Ashford Presbyterian HospitalColorectal Surgery Clinic, Ashford Presbyterian HospitalDepartment of Biochemistry and Medicine, School of Medicine, University of Puerto Rico Medical Sciences CampusDivision of Cancer Biology, University of Puerto Rico Comprehensive Cancer CenterAbstract Background Colorectal cancer (CRC) is the first cause of cancer deaths among Puerto Ricans. The incidence and mortality of CRC in Puerto Rico continue to be on the rise. The burden of CRC in Puerto Rico is higher than among US Hispanics and is second only to African Americans, thus supporting the importance of studying this CRC health disparity. The genetic background of the Puerto Rican population is a mix of European, African, and Amerindian races, which may account, in part, for the differences observed in the CRC mortality rates among Puerto Ricans. The objective of the study was to assess the role of genetic ancestry in CRC risk and its association with clinicopathological features of CRC tumors in Puerto Ricans. Results We used a validated panel of 105 ancestry informative markers (AIMs) to estimate genetic ancestry in 406 Puerto Rican CRC cases and 425 Puerto Rican controls. We examined the association of genetic ancestry with CRC risk and tumor clinicopathological characteristics. Conclusions The mean ancestry proportions in the study population were 61% European, 21% African, and 18% Amerindian. No association was observed between genetic ancestry and risk of CRC. However, African ancestry was associated with an increased risk of developing rectal tumors (OR = 1.55, 95% CI 1.04–2.31). Additional studies are needed to fully elucidate the role of African ancestry in CRC carcinogenesis.http://link.springer.com/article/10.1186/s40246-019-0196-4Colorectal cancerGenetic ancestryHispanicLatinosColorectal tumorsAfrican ancestry |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Julyann Pérez-Mayoral Marievelisse Soto-Salgado Ebony Shah Rick Kittles Mariana C. Stern Myrta I. Olivera María Gonzalez-Pons Segundo Rodriguez-Quilichinni Marla Torres Jose S. Reyes Luis Tous Nicolas López Victor Carlo Chevere Marcia Cruz-Correa |
spellingShingle |
Julyann Pérez-Mayoral Marievelisse Soto-Salgado Ebony Shah Rick Kittles Mariana C. Stern Myrta I. Olivera María Gonzalez-Pons Segundo Rodriguez-Quilichinni Marla Torres Jose S. Reyes Luis Tous Nicolas López Victor Carlo Chevere Marcia Cruz-Correa Association of genetic ancestry with colorectal tumor location in Puerto Rican Latinos Human Genomics Colorectal cancer Genetic ancestry Hispanic Latinos Colorectal tumors African ancestry |
author_facet |
Julyann Pérez-Mayoral Marievelisse Soto-Salgado Ebony Shah Rick Kittles Mariana C. Stern Myrta I. Olivera María Gonzalez-Pons Segundo Rodriguez-Quilichinni Marla Torres Jose S. Reyes Luis Tous Nicolas López Victor Carlo Chevere Marcia Cruz-Correa |
author_sort |
Julyann Pérez-Mayoral |
title |
Association of genetic ancestry with colorectal tumor location in Puerto Rican Latinos |
title_short |
Association of genetic ancestry with colorectal tumor location in Puerto Rican Latinos |
title_full |
Association of genetic ancestry with colorectal tumor location in Puerto Rican Latinos |
title_fullStr |
Association of genetic ancestry with colorectal tumor location in Puerto Rican Latinos |
title_full_unstemmed |
Association of genetic ancestry with colorectal tumor location in Puerto Rican Latinos |
title_sort |
association of genetic ancestry with colorectal tumor location in puerto rican latinos |
publisher |
BMC |
series |
Human Genomics |
issn |
1479-7364 |
publishDate |
2019-02-01 |
description |
Abstract Background Colorectal cancer (CRC) is the first cause of cancer deaths among Puerto Ricans. The incidence and mortality of CRC in Puerto Rico continue to be on the rise. The burden of CRC in Puerto Rico is higher than among US Hispanics and is second only to African Americans, thus supporting the importance of studying this CRC health disparity. The genetic background of the Puerto Rican population is a mix of European, African, and Amerindian races, which may account, in part, for the differences observed in the CRC mortality rates among Puerto Ricans. The objective of the study was to assess the role of genetic ancestry in CRC risk and its association with clinicopathological features of CRC tumors in Puerto Ricans. Results We used a validated panel of 105 ancestry informative markers (AIMs) to estimate genetic ancestry in 406 Puerto Rican CRC cases and 425 Puerto Rican controls. We examined the association of genetic ancestry with CRC risk and tumor clinicopathological characteristics. Conclusions The mean ancestry proportions in the study population were 61% European, 21% African, and 18% Amerindian. No association was observed between genetic ancestry and risk of CRC. However, African ancestry was associated with an increased risk of developing rectal tumors (OR = 1.55, 95% CI 1.04–2.31). Additional studies are needed to fully elucidate the role of African ancestry in CRC carcinogenesis. |
topic |
Colorectal cancer Genetic ancestry Hispanic Latinos Colorectal tumors African ancestry |
url |
http://link.springer.com/article/10.1186/s40246-019-0196-4 |
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