Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor

The hypoxic microenvironment in solid tumors limits the efficacy of photodynamic therapy (PDT) since oxygen is necessary to produce high cytotoxic singlet oxygen species. Here, the authors develop an improved self-assembled single-atom nanozyme which allows oxygen generation to enhance PDT efficacy.

Bibliographic Details
Main Authors: Dongdong Wang, Huihui Wu, Soo Zeng Fiona Phua, Guangbao Yang, Wei Qi Lim, Long Gu, Cheng Qian, Haibao Wang, Zhen Guo, Hongzhong Chen, Yanli Zhao
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-14199-7
Description
Summary:The hypoxic microenvironment in solid tumors limits the efficacy of photodynamic therapy (PDT) since oxygen is necessary to produce high cytotoxic singlet oxygen species. Here, the authors develop an improved self-assembled single-atom nanozyme which allows oxygen generation to enhance PDT efficacy.
ISSN:2041-1723