Concise anti-oxidative stress defence effects of Duvalia corderoyi in the liver and kidney tissues of streptozotocin-induced diabetic rats
The aim of the study was to evaluate the effect of Duvalia corderoyi (D. corderoyi) extracts in oxidative stress status and histopathology of liver and kidney tissues in streptozotocin (STZ)-induced diabetic rats. Fifty male Wistar albino rats were injected intraperitoneally (IP) with STZ. Rats with...
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doaj-a2f07a03660f478c8107b8a604249e2d2021-01-26T12:13:35ZengTaylor & Francis GroupJournal of Taibah University for Science1658-36552020-01-0114152453310.1080/16583655.2020.17519621751962Concise anti-oxidative stress defence effects of Duvalia corderoyi in the liver and kidney tissues of streptozotocin-induced diabetic ratsNora A. AlFaris0Ghedeir M. Alshammari1Muneer M. Alsayadi2Munirah A. AlFaris3Mohammed A. Yahya4Nutrition and Food Science (PHD), Department of Physical Sport Science, Princess Nourah Bint Abdulrahman UniversityDepartment of Food Science and Nutrition, College of Food and Agricultural Science, King Saud UniversityDepartment of Food Science and Technology, College of Agriculture, Ibb UniversityDepartment of Community Health Sciences, College of Applied Medical Sciences, King Saud UniversityDepartment of Food Science and Nutrition, College of Food and Agricultural Science, King Saud UniversityThe aim of the study was to evaluate the effect of Duvalia corderoyi (D. corderoyi) extracts in oxidative stress status and histopathology of liver and kidney tissues in streptozotocin (STZ)-induced diabetic rats. Fifty male Wistar albino rats were injected intraperitoneally (IP) with STZ. Rats with fasting blood glucose levels of 250 mg/dl and above were considered diabetic. Rats were subsequently fed orally with D. corderoyi extracts (100,200 mg/kg bw) for 30 days. Fasting blood glucose, insulin, and oxidative status in liver and kidney tissues were measured and histopathological analysis was performed. The blood glucose and malondialdehyde levels were decreased and the insulin, glutathione reductase, glutathione peroxidase, catalase, and superoxide dismutase levels were increased in D. corderoyi treated diabetic rats in comparison to those in untreated diabetic rats. Moreover, D. corderoyi relieved the injury in liver and kidney tissues of treated diabetic rats. Administration of D. corderoyi led to significant ameliorative effects on the oxidative stress and histopathology of liver and kidney tissues of D. corderoyi treated diabetic rats.http://dx.doi.org/10.1080/16583655.2020.1751962duvalia corderoyidiabetes mellitusoxidative stressreactive oxygen species |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nora A. AlFaris Ghedeir M. Alshammari Muneer M. Alsayadi Munirah A. AlFaris Mohammed A. Yahya |
spellingShingle |
Nora A. AlFaris Ghedeir M. Alshammari Muneer M. Alsayadi Munirah A. AlFaris Mohammed A. Yahya Concise anti-oxidative stress defence effects of Duvalia corderoyi in the liver and kidney tissues of streptozotocin-induced diabetic rats Journal of Taibah University for Science duvalia corderoyi diabetes mellitus oxidative stress reactive oxygen species |
author_facet |
Nora A. AlFaris Ghedeir M. Alshammari Muneer M. Alsayadi Munirah A. AlFaris Mohammed A. Yahya |
author_sort |
Nora A. AlFaris |
title |
Concise anti-oxidative stress defence effects of Duvalia corderoyi in the liver and kidney tissues of streptozotocin-induced diabetic rats |
title_short |
Concise anti-oxidative stress defence effects of Duvalia corderoyi in the liver and kidney tissues of streptozotocin-induced diabetic rats |
title_full |
Concise anti-oxidative stress defence effects of Duvalia corderoyi in the liver and kidney tissues of streptozotocin-induced diabetic rats |
title_fullStr |
Concise anti-oxidative stress defence effects of Duvalia corderoyi in the liver and kidney tissues of streptozotocin-induced diabetic rats |
title_full_unstemmed |
Concise anti-oxidative stress defence effects of Duvalia corderoyi in the liver and kidney tissues of streptozotocin-induced diabetic rats |
title_sort |
concise anti-oxidative stress defence effects of duvalia corderoyi in the liver and kidney tissues of streptozotocin-induced diabetic rats |
publisher |
Taylor & Francis Group |
series |
Journal of Taibah University for Science |
issn |
1658-3655 |
publishDate |
2020-01-01 |
description |
The aim of the study was to evaluate the effect of Duvalia corderoyi (D. corderoyi) extracts in oxidative stress status and histopathology of liver and kidney tissues in streptozotocin (STZ)-induced diabetic rats. Fifty male Wistar albino rats were injected intraperitoneally (IP) with STZ. Rats with fasting blood glucose levels of 250 mg/dl and above were considered diabetic. Rats were subsequently fed orally with D. corderoyi extracts (100,200 mg/kg bw) for 30 days. Fasting blood glucose, insulin, and oxidative status in liver and kidney tissues were measured and histopathological analysis was performed. The blood glucose and malondialdehyde levels were decreased and the insulin, glutathione reductase, glutathione peroxidase, catalase, and superoxide dismutase levels were increased in D. corderoyi treated diabetic rats in comparison to those in untreated diabetic rats. Moreover, D. corderoyi relieved the injury in liver and kidney tissues of treated diabetic rats. Administration of D. corderoyi led to significant ameliorative effects on the oxidative stress and histopathology of liver and kidney tissues of D. corderoyi treated diabetic rats. |
topic |
duvalia corderoyi diabetes mellitus oxidative stress reactive oxygen species |
url |
http://dx.doi.org/10.1080/16583655.2020.1751962 |
work_keys_str_mv |
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