Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector Binding
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| Format: | Article |
| Language: | English |
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American Chemical Society
2019-02-01
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| Series: | ACS Omega |
| Online Access: | http://dx.doi.org/10.1021/acsomega.8b03308 |
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doaj-a2f4b1b42550469ea496ea68f35e14d42020-11-25T03:17:44ZengAmerican Chemical SocietyACS Omega2470-13432019-02-01422921293010.1021/acsomega.8b03308Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector BindingMichael J. McCarthy0Cynthia V. Pagba1Priyanka Prakash2Ali K. Naji3Dharini van der Hoeven4Hong Liang5Amit K. Gupta6Yong Zhou7Kwang-Jin Cho8John F. Hancock9Alemayehu A. Gorfe10Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United StatesDepartment of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United StatesDepartment of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United StatesDepartment of Diagnostic and Biomedical Sciences, School of Dentistry, The University of Texas Health Science Center at Houston, Houston, Texas, United StatesDepartment of Diagnostic and Biomedical Sciences, School of Dentistry, The University of Texas Health Science Center at Houston, Houston, Texas, United StatesDepartment of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United StatesDepartment of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United StatesDepartment of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United StatesDepartment of Biochemistry and Molecular Biology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, United StatesDepartment of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United StatesDepartment of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United Stateshttp://dx.doi.org/10.1021/acsomega.8b03308 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Michael J. McCarthy Cynthia V. Pagba Priyanka Prakash Ali K. Naji Dharini van der Hoeven Hong Liang Amit K. Gupta Yong Zhou Kwang-Jin Cho John F. Hancock Alemayehu A. Gorfe |
| spellingShingle |
Michael J. McCarthy Cynthia V. Pagba Priyanka Prakash Ali K. Naji Dharini van der Hoeven Hong Liang Amit K. Gupta Yong Zhou Kwang-Jin Cho John F. Hancock Alemayehu A. Gorfe Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector Binding ACS Omega |
| author_facet |
Michael J. McCarthy Cynthia V. Pagba Priyanka Prakash Ali K. Naji Dharini van der Hoeven Hong Liang Amit K. Gupta Yong Zhou Kwang-Jin Cho John F. Hancock Alemayehu A. Gorfe |
| author_sort |
Michael J. McCarthy |
| title |
Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector Binding |
| title_short |
Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector Binding |
| title_full |
Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector Binding |
| title_fullStr |
Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector Binding |
| title_full_unstemmed |
Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector Binding |
| title_sort |
discovery of high-affinity noncovalent allosteric kras inhibitors that disrupt effector binding |
| publisher |
American Chemical Society |
| series |
ACS Omega |
| issn |
2470-1343 |
| publishDate |
2019-02-01 |
| url |
http://dx.doi.org/10.1021/acsomega.8b03308 |
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