Association of asthma comorbidity with poor prognosis of coronavirus disease 2019
Background: While global health agencies have listed asthma as a vulnerability for severe cases of coronavirus disease 2019 (COVID-19), the evidence supporting this is scarce. Methods: A nationwide cohort study was conducted using the validated Korean national health insurance claim data of patients...
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doaj-a2fbaa60ba094bcc96372434d2ff9e5e2021-09-23T04:37:30ZengElsevierWorld Allergy Organization Journal1939-45512021-08-01148100576Association of asthma comorbidity with poor prognosis of coronavirus disease 2019Sae-Hoon Kim0Eunjeong Ji1Seung-Hyun Won2Jungwon Cho3Yong-Hyun Kim4Soyeon Ahn5Yoon-Seok Chang6Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South KoreaDivision of Statistics, Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, South KoreaDivision of Statistics, Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, South KoreaDepartment of Pharmacy, Seoul National University Bundang Hospital, Seongnam, South KoreaInstitute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South KoreaDivision of Statistics, Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, South Korea; Corresponding author. Division of Statistics, Medical Research Collaborating Center, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam, South KoreaDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea; Corresponding author. Department of Internal Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam, South KoreaBackground: While global health agencies have listed asthma as a vulnerability for severe cases of coronavirus disease 2019 (COVID-19), the evidence supporting this is scarce. Methods: A nationwide cohort study was conducted using the validated Korean national health insurance claim data of patients diagnosed with COVID-19 between January 1 and April 8, 2020. Asthma comorbidity was determined using a diagnosis code assigned by the physician and the prescription of asthma-related medications. The clinical course of COVID-19 was classified into 3 severity grades according to the requirements for oxygen supply and mechanical ventilation. We also evaluated the association of asthma with overall and in-hospital mortality of COVID-19. Results: Asthma morbidity was a significant risk factor for severe COVID-19 (grade 2 requiring oxygen supply) (adjusted odds ratio [aOR] = 1.341, 95% confidence interval [CI], 1.051−1.711, P = 0.018) and grade 3 requiring mechanical ventilation or leading to death (aOR = 1.723, 95% CI: 1.230−2.412, P = 0.002) multinomial logistic regression adjusting co-risk factors. Asthma was also significantly associated with mortality of COVID-19 (aOR = 1.453, 95% CI: 1.015−2.080, P = 0.041) and was revealed to have a shorter time to in-hospital mortality of COVID-19 (P < 0.001). Patients with recent asthma exacerbation showed more severe COVID-19 of grade 3 (OR = 7.371, 95% CI: 2.018−26.924, P = 0.003) and higher mortality (OR = 9.208, 95% CI: 2.597−32.646, P < 0.001) in univariable analysis, but the statistical significance was not found in multivariable analysis. Conclusion: Asthma morbidity was associated with severity and mortality of COVID-19. Patients with asthma should pay more attention to avoid worsening of COVID-19.http://www.sciencedirect.com/science/article/pii/S1939455121000703AsthmaCOVID-19Exacerbation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sae-Hoon Kim Eunjeong Ji Seung-Hyun Won Jungwon Cho Yong-Hyun Kim Soyeon Ahn Yoon-Seok Chang |
spellingShingle |
Sae-Hoon Kim Eunjeong Ji Seung-Hyun Won Jungwon Cho Yong-Hyun Kim Soyeon Ahn Yoon-Seok Chang Association of asthma comorbidity with poor prognosis of coronavirus disease 2019 World Allergy Organization Journal Asthma COVID-19 Exacerbation |
author_facet |
Sae-Hoon Kim Eunjeong Ji Seung-Hyun Won Jungwon Cho Yong-Hyun Kim Soyeon Ahn Yoon-Seok Chang |
author_sort |
Sae-Hoon Kim |
title |
Association of asthma comorbidity with poor prognosis of coronavirus disease 2019 |
title_short |
Association of asthma comorbidity with poor prognosis of coronavirus disease 2019 |
title_full |
Association of asthma comorbidity with poor prognosis of coronavirus disease 2019 |
title_fullStr |
Association of asthma comorbidity with poor prognosis of coronavirus disease 2019 |
title_full_unstemmed |
Association of asthma comorbidity with poor prognosis of coronavirus disease 2019 |
title_sort |
association of asthma comorbidity with poor prognosis of coronavirus disease 2019 |
publisher |
Elsevier |
series |
World Allergy Organization Journal |
issn |
1939-4551 |
publishDate |
2021-08-01 |
description |
Background: While global health agencies have listed asthma as a vulnerability for severe cases of coronavirus disease 2019 (COVID-19), the evidence supporting this is scarce. Methods: A nationwide cohort study was conducted using the validated Korean national health insurance claim data of patients diagnosed with COVID-19 between January 1 and April 8, 2020. Asthma comorbidity was determined using a diagnosis code assigned by the physician and the prescription of asthma-related medications. The clinical course of COVID-19 was classified into 3 severity grades according to the requirements for oxygen supply and mechanical ventilation. We also evaluated the association of asthma with overall and in-hospital mortality of COVID-19. Results: Asthma morbidity was a significant risk factor for severe COVID-19 (grade 2 requiring oxygen supply) (adjusted odds ratio [aOR] = 1.341, 95% confidence interval [CI], 1.051−1.711, P = 0.018) and grade 3 requiring mechanical ventilation or leading to death (aOR = 1.723, 95% CI: 1.230−2.412, P = 0.002) multinomial logistic regression adjusting co-risk factors. Asthma was also significantly associated with mortality of COVID-19 (aOR = 1.453, 95% CI: 1.015−2.080, P = 0.041) and was revealed to have a shorter time to in-hospital mortality of COVID-19 (P < 0.001). Patients with recent asthma exacerbation showed more severe COVID-19 of grade 3 (OR = 7.371, 95% CI: 2.018−26.924, P = 0.003) and higher mortality (OR = 9.208, 95% CI: 2.597−32.646, P < 0.001) in univariable analysis, but the statistical significance was not found in multivariable analysis. Conclusion: Asthma morbidity was associated with severity and mortality of COVID-19. Patients with asthma should pay more attention to avoid worsening of COVID-19. |
topic |
Asthma COVID-19 Exacerbation |
url |
http://www.sciencedirect.com/science/article/pii/S1939455121000703 |
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