CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension

CD146-HIF-1α hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension

Vascular remodelling contributes to the development of pulmonary hypertension (PH). Here Luo and colleagues find that increases in CD146 levels drive vascular remodelling in PH through a cross-talk with hypoxia inducible factor (HIF) signalling, and show that inhibition of CD146 can attenuate diseas...

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Bibliographic Details
Main Authors: Yongting Luo, Xiao Teng, Lingling Zhang, Jianan Chen, Zheng Liu, Xuehui Chen, Shuai Zhao, Sai Yang, Jing Feng, Xiyun Yan
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11500-6
Description
Summary:Vascular remodelling contributes to the development of pulmonary hypertension (PH). Here Luo and colleagues find that increases in CD146 levels drive vascular remodelling in PH through a cross-talk with hypoxia inducible factor (HIF) signalling, and show that inhibition of CD146 can attenuate disease progression.
ISSN:2041-1723

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