A comprehensive overview of genomic imprinting in breast and its deregulation in cancer

A comprehensive overview of genomic imprinting in breast and its deregulation in cancer

In growth and development genomic imprinting is important in regulating gene expression. Here, the authors study loss of imprinting (LOI) in cancer, developing a mixture model to detect monoallelically expressed loci without genotyping data - applying this novel methodology to TCGA breast cancer dat...

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Main Authors: Tine Goovaerts, Sandra Steyaert, Chari A. Vandenbussche, Jeroen Galle, Olivier Thas, Wim Van Criekinge, Tim De Meyer
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06566-7
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spelling doaj-a31747ded3ca420d952e1b5d3be9291b2021-05-11T10:26:11ZengNature Publishing GroupNature Communications2041-17232018-10-019111410.1038/s41467-018-06566-7A comprehensive overview of genomic imprinting in breast and its deregulation in cancerTine Goovaerts0Sandra Steyaert1Chari A. Vandenbussche2Jeroen Galle3Olivier Thas4Wim Van Criekinge5Tim De Meyer6Department Data Analysis and Mathematical Modelling, Ghent UniversityDepartment Data Analysis and Mathematical Modelling, Ghent UniversityDepartment Data Analysis and Mathematical Modelling, Ghent UniversityDepartment Data Analysis and Mathematical Modelling, Ghent UniversityDepartment Data Analysis and Mathematical Modelling, Ghent UniversityDepartment Data Analysis and Mathematical Modelling, Ghent UniversityDepartment Data Analysis and Mathematical Modelling, Ghent UniversityIn growth and development genomic imprinting is important in regulating gene expression. Here, the authors study loss of imprinting (LOI) in cancer, developing a mixture model to detect monoallelically expressed loci without genotyping data - applying this novel methodology to TCGA breast cancer data they find massive deregulation of imprinting.https://doi.org/10.1038/s41467-018-06566-7
collection DOAJ
language English
format Article
sources DOAJ
author Tine Goovaerts
Sandra Steyaert
Chari A. Vandenbussche
Jeroen Galle
Olivier Thas
Wim Van Criekinge
Tim De Meyer
spellingShingle Tine Goovaerts
Sandra Steyaert
Chari A. Vandenbussche
Jeroen Galle
Olivier Thas
Wim Van Criekinge
Tim De Meyer
A comprehensive overview of genomic imprinting in breast and its deregulation in cancer
Nature Communications
author_facet Tine Goovaerts
Sandra Steyaert
Chari A. Vandenbussche
Jeroen Galle
Olivier Thas
Wim Van Criekinge
Tim De Meyer
author_sort Tine Goovaerts
title A comprehensive overview of genomic imprinting in breast and its deregulation in cancer
title_short A comprehensive overview of genomic imprinting in breast and its deregulation in cancer
title_full A comprehensive overview of genomic imprinting in breast and its deregulation in cancer
title_fullStr A comprehensive overview of genomic imprinting in breast and its deregulation in cancer
title_full_unstemmed A comprehensive overview of genomic imprinting in breast and its deregulation in cancer
title_sort comprehensive overview of genomic imprinting in breast and its deregulation in cancer
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-10-01
description In growth and development genomic imprinting is important in regulating gene expression. Here, the authors study loss of imprinting (LOI) in cancer, developing a mixture model to detect monoallelically expressed loci without genotyping data - applying this novel methodology to TCGA breast cancer data they find massive deregulation of imprinting.
url https://doi.org/10.1038/s41467-018-06566-7
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