Amomum villosum Lour. fruit extract ameliorates high-fat diet-induced body mass gain and adipogenic pathways in C57BL/6 mice
Amomum villosum Lour. is commonly used in Asian countries as an herbal remedy to medicate several diseases including type 2 diabetes. In this animal experiment, we examined the influence of Amomum villosum water extract (AVE) against metabolic variations in high-fat diet (HFD)-induced obesity in C57...
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doaj-a317ebd126844e7296159d1753d01e872021-06-17T04:45:45ZengElsevierJournal of King Saud University: Science1018-36472021-07-01335101473Amomum villosum Lour. fruit extract ameliorates high-fat diet-induced body mass gain and adipogenic pathways in C57BL/6 miceHa-Rim Kim0Paulrayer Antonisamy1Ye-Seul Kim2Yong-Gwan Kwon3Do-Gon Ryu4Young-Rae Lee5Guemsan Lee6Hyang-Do Ham7Kang-Beom Kwon8Ilwonbio Co. Ltd, & Department of Physiology, Wonkwang University School of Korean Medicine, Iksan, Jeonbuk, South KoreaIlwonbio Co. Ltd, & Department of Physiology, Wonkwang University School of Korean Medicine, Iksan, Jeonbuk, South KoreaIlwonbio Co. Ltd, & Department of Physiology, Wonkwang University School of Korean Medicine, Iksan, Jeonbuk, South KoreaIlwonbio Co. Ltd, & Department of Physiology, Wonkwang University School of Korean Medicine, Iksan, Jeonbuk, South KoreaIlwonbio Co. Ltd, & Department of Physiology, Wonkwang University School of Korean Medicine, Iksan, Jeonbuk, South KoreaDepartment of Oral Biochemistry, Institute of Biomaterials, Implant, Wonkwang University School of Dentistry, Iksan, Jeonbuk, South KoreaDepartment of Herbology, Wonkwang University School of Korean Medicine, Iksan, Jeonbuk, South KoreaDepartment of Anesthesiology and Pain Medicine, Wonkwang University School of Medicine, Wonkwang University Hospital, 460 Iksan-daero, Iksan, Jeonbuk 54538, South Korea; Corresponding authors at: Ilwonbio Co., Ltd., & Department of Physiology, Wonkwang University School of Korean Medicine, Iksandaero 460, Iksan, Jeonbuk, 54538, South Korea. Tel: +82-63-850-6917; Fax: +82-63-842-3138; (Kang-Beom Kwon). Department of Anesthesiology and Pain Medicine, Wonkwang University School of Medicine, Wonkwang University Hospital, 460 Iksan-daero, Iksan, Jeonbuk 54538, South Korea. Tel: +82-63-859-1560; Fax: +82-63-859-5472; (Hyang-Do Ham).Ilwonbio Co. Ltd, & Department of Physiology, Wonkwang University School of Korean Medicine, Iksan, Jeonbuk, South Korea; Corresponding authors at: Ilwonbio Co., Ltd., & Department of Physiology, Wonkwang University School of Korean Medicine, Iksandaero 460, Iksan, Jeonbuk, 54538, South Korea. Tel: +82-63-850-6917; Fax: +82-63-842-3138; (Kang-Beom Kwon). Department of Anesthesiology and Pain Medicine, Wonkwang University School of Medicine, Wonkwang University Hospital, 460 Iksan-daero, Iksan, Jeonbuk 54538, South Korea. Tel: +82-63-859-1560; Fax: +82-63-859-5472; (Hyang-Do Ham).Amomum villosum Lour. is commonly used in Asian countries as an herbal remedy to medicate several diseases including type 2 diabetes. In this animal experiment, we examined the influence of Amomum villosum water extract (AVE) against metabolic variations in high-fat diet (HFD)-induced obesity in C57BL/6 mice. Mice were nourishing with a normal diet (control), high-fat diet (HFD), HFD + AVE 100 mg/kg body weight (b.wt.)/day, HFD + AVE 200 mg/kg b.wt./day, and HFD + AVE 500 mg/kg b.wt./day for 7 weeks. The AVE (100, 200, and 500 mg/kg)-treated animals exhibited substantial decreases in body mass, fat mass, adipocyte hypertrophy, and epididymal white adipose tissue (eWAT) collate to the HFD-fed group. AVE treatment also reduced hepatic triglyceride level and significantly increased the adiponectin expression in adipocytes. Furthermore, AVE treatment significantly inhibited adipogenesis in the AVE group by reducing the mRNA expression of sterol regulatory element-binding protein1 (SREBP1), fatty acid synthase (FAS), CCAAT/enhancer binding protein (C/EBP)-α, peroxisome proliferator-activated receptor (PPAR)-γ, and tumor necrosis factor (TNF)-α agreeing to the HFD-fed animals. These research outcomes recommend that AVE is possibly valuable for the prevention of HFD-induced obesity via modification of various pathways related with adipogenesis and food consumption.http://www.sciencedirect.com/science/article/pii/S1018364721001348Amomum villosumAdipogenesisHFD-induced obesityFASSREBP1PPAR-γ |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ha-Rim Kim Paulrayer Antonisamy Ye-Seul Kim Yong-Gwan Kwon Do-Gon Ryu Young-Rae Lee Guemsan Lee Hyang-Do Ham Kang-Beom Kwon |
spellingShingle |
Ha-Rim Kim Paulrayer Antonisamy Ye-Seul Kim Yong-Gwan Kwon Do-Gon Ryu Young-Rae Lee Guemsan Lee Hyang-Do Ham Kang-Beom Kwon Amomum villosum Lour. fruit extract ameliorates high-fat diet-induced body mass gain and adipogenic pathways in C57BL/6 mice Journal of King Saud University: Science Amomum villosum Adipogenesis HFD-induced obesity FAS SREBP1 PPAR-γ |
author_facet |
Ha-Rim Kim Paulrayer Antonisamy Ye-Seul Kim Yong-Gwan Kwon Do-Gon Ryu Young-Rae Lee Guemsan Lee Hyang-Do Ham Kang-Beom Kwon |
author_sort |
Ha-Rim Kim |
title |
Amomum villosum Lour. fruit extract ameliorates high-fat diet-induced body mass gain and adipogenic pathways in C57BL/6 mice |
title_short |
Amomum villosum Lour. fruit extract ameliorates high-fat diet-induced body mass gain and adipogenic pathways in C57BL/6 mice |
title_full |
Amomum villosum Lour. fruit extract ameliorates high-fat diet-induced body mass gain and adipogenic pathways in C57BL/6 mice |
title_fullStr |
Amomum villosum Lour. fruit extract ameliorates high-fat diet-induced body mass gain and adipogenic pathways in C57BL/6 mice |
title_full_unstemmed |
Amomum villosum Lour. fruit extract ameliorates high-fat diet-induced body mass gain and adipogenic pathways in C57BL/6 mice |
title_sort |
amomum villosum lour. fruit extract ameliorates high-fat diet-induced body mass gain and adipogenic pathways in c57bl/6 mice |
publisher |
Elsevier |
series |
Journal of King Saud University: Science |
issn |
1018-3647 |
publishDate |
2021-07-01 |
description |
Amomum villosum Lour. is commonly used in Asian countries as an herbal remedy to medicate several diseases including type 2 diabetes. In this animal experiment, we examined the influence of Amomum villosum water extract (AVE) against metabolic variations in high-fat diet (HFD)-induced obesity in C57BL/6 mice. Mice were nourishing with a normal diet (control), high-fat diet (HFD), HFD + AVE 100 mg/kg body weight (b.wt.)/day, HFD + AVE 200 mg/kg b.wt./day, and HFD + AVE 500 mg/kg b.wt./day for 7 weeks. The AVE (100, 200, and 500 mg/kg)-treated animals exhibited substantial decreases in body mass, fat mass, adipocyte hypertrophy, and epididymal white adipose tissue (eWAT) collate to the HFD-fed group. AVE treatment also reduced hepatic triglyceride level and significantly increased the adiponectin expression in adipocytes. Furthermore, AVE treatment significantly inhibited adipogenesis in the AVE group by reducing the mRNA expression of sterol regulatory element-binding protein1 (SREBP1), fatty acid synthase (FAS), CCAAT/enhancer binding protein (C/EBP)-α, peroxisome proliferator-activated receptor (PPAR)-γ, and tumor necrosis factor (TNF)-α agreeing to the HFD-fed animals. These research outcomes recommend that AVE is possibly valuable for the prevention of HFD-induced obesity via modification of various pathways related with adipogenesis and food consumption. |
topic |
Amomum villosum Adipogenesis HFD-induced obesity FAS SREBP1 PPAR-γ |
url |
http://www.sciencedirect.com/science/article/pii/S1018364721001348 |
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