Combined subtractive cDNA cloning and array CGH: an efficient approach for identification of overexpressed genes in DNA amplicons

Combined subtractive cDNA cloning and array CGH: an efficient approach for identification of overexpressed genes in DNA amplicons

<p>Abstract</p> <p>Background</p> <p>Activation of proto-oncogenes by DNA amplification is an important mechanism in the development and maintenance of cancer cells. Until recently, identification of the targeted genes relied on labour intensive and time consuming posit...

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Bibliographic Details
Main Authors: De Paepe Anne, Van Roy Frans, Menten Björn, Strumane Kristin, Pattyn Filip, Berx Geert, De Preter Katleen, Speleman Frank, Vandesompele Jo
Format: Article
Language:English
Published: BMC 2004-02-01
Series:BMC Genomics
Subjects:
Amplification
Overexpression
Oncogene
SSH
Array CGH
Neuroblastoma
Online Access:http://www.biomedcentral.com/1471-2164/5/11

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