Assessment of Serum Vaspin Levels among Type 2 Diabetes Mellitus Patients with or without Acute Coronary Syndrome
Introduction: Type 2 Diabetes Mellitus (DM) is on the verge of becoming a pandemic in India. Type 2 DM patient have two to four times increased risk of carotid artery disease. Adipokines have been regarded recently as direct link between diabetes and atherosclerosis. Visceral Adipose Tissue Deri...
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doaj-a32a98a5c1c246f3b5e2d13d72ee5c3d2020-11-25T02:17:08ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-12-011012BC07BC1010.7860/JCDR/2016/22417.8952Assessment of Serum Vaspin Levels among Type 2 Diabetes Mellitus Patients with or without Acute Coronary SyndromeAswathy Jaya Sathyaseelan0Prashant Shankarrao Adole1Mukta Wyawahare2Rama Prakasha Saya3Student, Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.Assistant Professor, Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.Associate Professor, Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.Associate Professor, Department of Medicine, Kanachur Institute of Medical Sciences & Research Center, Mangalore, Andhra Pradesh, India.Introduction: Type 2 Diabetes Mellitus (DM) is on the verge of becoming a pandemic in India. Type 2 DM patient have two to four times increased risk of carotid artery disease. Adipokines have been regarded recently as direct link between diabetes and atherosclerosis. Visceral Adipose Tissue Derived Serine Protease Inhibitor (VASPIN); one of the most recently discovered adipokine, inhibits the proteases responsible for insulin resistance, carotid plaque development and rupture. In literature, few studies have addressed the role of vaspin in pathogenesis of Acute Coronary Syndrome (ACS) in patients with type 2 DM. Aim: To find association between serum vaspin with lipid profile, creatine kinase-total, creatine kinase-MB, troponin-I, age, height, weight, blood pressure, smoking, family history of ACS and to prove the hypothesis of low serum vaspin level as predictor of ACS in patients with type 2 DM. Materials and Methods: Forty-one type 2 DM patients (controls) and 41 type 2 DM patients with ACS (cases) were enrolled in the study. Anthropometric measurements were performed and fasting serum biochemical parameters and vaspin were measured. The results of cases and controls were compared by student t-test or Mann–Whitney test. All the parameters were correlated with serum vaspin by Pearson’s or Spearman’s correlation. Results: Fasting serum vaspin concentration was significantly (p< 0.0001) lower in the cases (0.43±0.22 pg/ml) than in the controls (0.83±0.29 pg/ml). Correlation analysis undertaken on all type 2 DM showed that serum vaspin concentration was negatively correlated with age, waist circumference, hip circumference, systolic and diastolic blood pressure, duration of diabetes, serum Creative Kinase-Total, CK-MB and urea (p< 0.05). Utilizing Receiver Operating Characteristic (ROC) curve, the serum vaspin level of less than 0.594pg/ml showed greatest risk of ACS among type 2 DM patients (p< 0.0001). Conclusion: Type 2 DM patients with low serum vaspin concentration were at risk of ACS independent of other cardiovascular risk factors.https://jcdr.net/articles/PDF/8952/22417_CE[Ra]_F(Sh)_PF1(AH_RK)_PFA(AK)_PF2(PAG).pdfadipokinescoronary artery diseasediabetic patients |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aswathy Jaya Sathyaseelan Prashant Shankarrao Adole Mukta Wyawahare Rama Prakasha Saya |
spellingShingle |
Aswathy Jaya Sathyaseelan Prashant Shankarrao Adole Mukta Wyawahare Rama Prakasha Saya Assessment of Serum Vaspin Levels among Type 2 Diabetes Mellitus Patients with or without Acute Coronary Syndrome Journal of Clinical and Diagnostic Research adipokines coronary artery disease diabetic patients |
author_facet |
Aswathy Jaya Sathyaseelan Prashant Shankarrao Adole Mukta Wyawahare Rama Prakasha Saya |
author_sort |
Aswathy Jaya Sathyaseelan |
title |
Assessment of Serum Vaspin Levels among Type 2 Diabetes Mellitus Patients with or without Acute Coronary Syndrome |
title_short |
Assessment of Serum Vaspin Levels among Type 2 Diabetes Mellitus Patients with or without Acute Coronary Syndrome |
title_full |
Assessment of Serum Vaspin Levels among Type 2 Diabetes Mellitus Patients with or without Acute Coronary Syndrome |
title_fullStr |
Assessment of Serum Vaspin Levels among Type 2 Diabetes Mellitus Patients with or without Acute Coronary Syndrome |
title_full_unstemmed |
Assessment of Serum Vaspin Levels among Type 2 Diabetes Mellitus Patients with or without Acute Coronary Syndrome |
title_sort |
assessment of serum vaspin levels among type 2 diabetes mellitus patients with or without acute coronary syndrome |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2016-12-01 |
description |
Introduction: Type 2 Diabetes Mellitus (DM) is on the verge
of becoming a pandemic in India. Type 2 DM patient have
two to four times increased risk of carotid artery disease.
Adipokines have been regarded recently as direct link between
diabetes and atherosclerosis. Visceral Adipose Tissue Derived
Serine Protease Inhibitor (VASPIN); one of the most recently
discovered adipokine, inhibits the proteases responsible for
insulin resistance, carotid plaque development and rupture.
In literature, few studies have addressed the role of vaspin in
pathogenesis of Acute Coronary Syndrome (ACS) in patients
with type 2 DM.
Aim: To find association between serum vaspin with lipid
profile, creatine kinase-total, creatine kinase-MB, troponin-I,
age, height, weight, blood pressure, smoking, family history of
ACS and to prove the hypothesis of low serum vaspin level as
predictor of ACS in patients with type 2 DM.
Materials and Methods: Forty-one type 2 DM patients (controls)
and 41 type 2 DM patients with ACS (cases) were enrolled in
the study. Anthropometric measurements were performed
and fasting serum biochemical parameters and vaspin were
measured. The results of cases and controls were compared by
student t-test or Mann–Whitney test. All the parameters were
correlated with serum vaspin by Pearson’s or Spearman’s
correlation.
Results: Fasting serum vaspin concentration was significantly
(p< 0.0001) lower in the cases (0.43±0.22 pg/ml) than in the
controls (0.83±0.29 pg/ml). Correlation analysis undertaken
on all type 2 DM showed that serum vaspin concentration
was negatively correlated with age, waist circumference, hip
circumference, systolic and diastolic blood pressure, duration
of diabetes, serum Creative Kinase-Total, CK-MB and urea
(p< 0.05). Utilizing Receiver Operating Characteristic (ROC)
curve, the serum vaspin level of less than 0.594pg/ml showed
greatest risk of ACS among type 2 DM patients (p< 0.0001).
Conclusion: Type 2 DM patients with low serum vaspin
concentration were at risk of ACS independent of other
cardiovascular risk factors. |
topic |
adipokines coronary artery disease diabetic patients |
url |
https://jcdr.net/articles/PDF/8952/22417_CE[Ra]_F(Sh)_PF1(AH_RK)_PFA(AK)_PF2(PAG).pdf |
work_keys_str_mv |
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