The Experiential Comparison of Levetiracetam Efficacy in Migraine Headache with Sodium Valproate
Background: Migraine and other recurrent headaches are considered a major public health concern. Levetiracetam, a broad spectrum anti-epileptic have been used in migraine prophylaxis. Objectives: Assessment the efficacy of levetiracetam on migraine in comparison to sodium valproate. Materials and...
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Guilan University of Medical Sciences
2016-06-01
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doaj-a33070396a484ab6957e29a94ff4eac02020-11-24T21:56:36ZengGuilan University of Medical SciencesCaspian Journal of Neurological Sciences2383-43072423-48182016-06-01254249The Experiential Comparison of Levetiracetam Efficacy in Migraine Headache with Sodium ValproateMehran Homam0Arezou Farajpour1Saman Khadem2Zahra Mostafavian3 Assistant Professor of Neurology, Mashhad Branch, Islamic Azad University, Mashhad, Iran PhD Candidate of Medical Education, Shahid Beheshti University of Medical Sciences, Tehran, Iran Faculty of Medical Education, Mashhad Branch, Islamic Azad University, Mashhad, Iran Assistant Professor of Community Medicine, Mashhad Branch, Islamic Azad University, Mashhad, Iran ; dr.mostafavian@mshdiau.ac.ir Background: Migraine and other recurrent headaches are considered a major public health concern. Levetiracetam, a broad spectrum anti-epileptic have been used in migraine prophylaxis. Objectives: Assessment the efficacy of levetiracetam on migraine in comparison to sodium valproate. Materials and Methods: This randomized double blind clinical trial was performed on patients with migraine headache, diagnosed based on ICDH-version B criteria. One group received levetiracetam and the other group received valproate sodium. The number of migraine attacks per month, the mean duration of attacks and the intensity of pain (VAS) and disability due to headache (MIDAS) were assessed at first and after four weeks of treatment. Data were analyzed in SPSS 20 by Mann-Whitney-U and Chi-square tests. The significance level was set<0.05. Results: Thirty patients (28 women and 2 men, mean age of 35.14±7.3 years) remained in the valproate group and 33 patients (31women and 2 men, mean age of 36.33±6.7 years) in the levetiracetam group. The patients in both groups showed a statistically significant reduction in the frequency of headache (p=0.0001); intensity of headache (p=0.004); mean duration of attacks (p=0.0001) and MIDAS score of disability (p=0.004) compared to baseline. There was also a statistically significant difference between the two groups in terms of frequency of attacks (p=0.0001), intensity of pain (p=0.0001); and MIDAS score (p=0.0001), by the end of the treatment with superiority of levetiracetam. Conclusion: Levetiracetam, compared to valproate, yielded better results in prophylaxis of migraine headache.http://cjns.gums.ac.ir/browse.php?a_code=A-10-32-38&slc_lang=en&sid=1LevetiracetamMigraine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mehran Homam Arezou Farajpour Saman Khadem Zahra Mostafavian |
spellingShingle |
Mehran Homam Arezou Farajpour Saman Khadem Zahra Mostafavian The Experiential Comparison of Levetiracetam Efficacy in Migraine Headache with Sodium Valproate Caspian Journal of Neurological Sciences Levetiracetam Migraine |
author_facet |
Mehran Homam Arezou Farajpour Saman Khadem Zahra Mostafavian |
author_sort |
Mehran Homam |
title |
The Experiential Comparison of Levetiracetam Efficacy in Migraine Headache with Sodium Valproate |
title_short |
The Experiential Comparison of Levetiracetam Efficacy in Migraine Headache with Sodium Valproate |
title_full |
The Experiential Comparison of Levetiracetam Efficacy in Migraine Headache with Sodium Valproate |
title_fullStr |
The Experiential Comparison of Levetiracetam Efficacy in Migraine Headache with Sodium Valproate |
title_full_unstemmed |
The Experiential Comparison of Levetiracetam Efficacy in Migraine Headache with Sodium Valproate |
title_sort |
experiential comparison of levetiracetam efficacy in migraine headache with sodium valproate |
publisher |
Guilan University of Medical Sciences |
series |
Caspian Journal of Neurological Sciences |
issn |
2383-4307 2423-4818 |
publishDate |
2016-06-01 |
description |
Background: Migraine and other recurrent headaches are considered a major public health concern. Levetiracetam, a broad spectrum anti-epileptic have been used in migraine prophylaxis.
Objectives: Assessment the efficacy of levetiracetam on migraine in comparison to sodium valproate.
Materials and Methods: This randomized double blind clinical trial was performed on patients with migraine headache, diagnosed based on ICDH-version B criteria. One group received levetiracetam and the other group received valproate sodium. The number of migraine attacks per month, the mean duration of attacks and the intensity of pain (VAS) and disability due to headache (MIDAS) were assessed at first and after four weeks of treatment. Data were analyzed in SPSS 20 by Mann-Whitney-U and Chi-square tests. The significance level was set<0.05.
Results: Thirty patients (28 women and 2 men, mean age of 35.14±7.3 years) remained in the valproate group and 33 patients (31women and 2 men, mean age of 36.33±6.7 years) in the levetiracetam group. The patients in both groups showed a statistically significant reduction in the frequency of headache (p=0.0001); intensity of headache (p=0.004); mean duration of attacks (p=0.0001) and MIDAS score of disability (p=0.004) compared to baseline. There was also a statistically significant difference between the two groups in terms of frequency of attacks (p=0.0001), intensity of pain (p=0.0001); and MIDAS score (p=0.0001), by the end of the treatment with superiority of levetiracetam.
Conclusion: Levetiracetam, compared to valproate, yielded better results in prophylaxis of migraine headache. |
topic |
Levetiracetam Migraine |
url |
http://cjns.gums.ac.ir/browse.php?a_code=A-10-32-38&slc_lang=en&sid=1 |
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