Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy

A common failure of many cancer treatments is attributed to the resistance imparted by tumour hypoxia. Here, the authors report on the generic synthesis of small-sized hollow mesoporous organosilica nanoparticles which are designed for oxygen-independent X-ray-activated synergistic therapy.

Bibliographic Details
Main Authors:	Wenpei Fan, Nan Lu, Zheyu Shen, Wei Tang, Bo Shen, Zhaowen Cui, Lingling Shan, Zhen Yang, Zhantong Wang, Orit Jacobson, Zijian Zhou, Yijing Liu, Ping Hu, Weijing Yang, Jibin Song, Yang Zhang, Liwen Zhang, Niveen M. Khashab, Maria A. Aronova, Guangming Lu, Xiaoyuan Chen
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-09158-1

id	doaj-a33428d6ae6947ed8bb47a3b9835cc6e
record_format	Article
spelling	doaj-a33428d6ae6947ed8bb47a3b9835cc6e2021-05-11T12:06:58ZengNature Publishing GroupNature Communications2041-17232019-03-0110111410.1038/s41467-019-09158-1Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapyWenpei Fan0Nan Lu1Zheyu Shen2Wei Tang3Bo Shen4Zhaowen Cui5Lingling Shan6Zhen Yang7Zhantong Wang8Orit Jacobson9Zijian Zhou10Yijing Liu11Ping Hu12Weijing Yang13Jibin Song14Yang Zhang15Liwen Zhang16Niveen M. Khashab17Maria A. Aronova18Guangming Lu19Xiaoyuan Chen20Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthDepartment of Radiology, the Second Affiliated Hospital, Zhejiang University School of MedicineLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthInstitute of Radiation Medicine, Fudan UniversityState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of SciencesLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of SciencesLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthSmart Hybrid Materials Laboratory (SHMs), Advanced Membranes and Porous Materials Center, King Abdullah University of Science and TechnologySmart Hybrid Materials Laboratory (SHMs), Advanced Membranes and Porous Materials Center, King Abdullah University of Science and TechnologySmart Hybrid Materials Laboratory (SHMs), Advanced Membranes and Porous Materials Center, King Abdullah University of Science and TechnologyLaboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing UniversityLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthA common failure of many cancer treatments is attributed to the resistance imparted by tumour hypoxia. Here, the authors report on the generic synthesis of small-sized hollow mesoporous organosilica nanoparticles which are designed for oxygen-independent X-ray-activated synergistic therapy.https://doi.org/10.1038/s41467-019-09158-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Wenpei Fan Nan Lu Zheyu Shen Wei Tang Bo Shen Zhaowen Cui Lingling Shan Zhen Yang Zhantong Wang Orit Jacobson Zijian Zhou Yijing Liu Ping Hu Weijing Yang Jibin Song Yang Zhang Liwen Zhang Niveen M. Khashab Maria A. Aronova Guangming Lu Xiaoyuan Chen
spellingShingle	Wenpei Fan Nan Lu Zheyu Shen Wei Tang Bo Shen Zhaowen Cui Lingling Shan Zhen Yang Zhantong Wang Orit Jacobson Zijian Zhou Yijing Liu Ping Hu Weijing Yang Jibin Song Yang Zhang Liwen Zhang Niveen M. Khashab Maria A. Aronova Guangming Lu Xiaoyuan Chen Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy Nature Communications
author_facet	Wenpei Fan Nan Lu Zheyu Shen Wei Tang Bo Shen Zhaowen Cui Lingling Shan Zhen Yang Zhantong Wang Orit Jacobson Zijian Zhou Yijing Liu Ping Hu Weijing Yang Jibin Song Yang Zhang Liwen Zhang Niveen M. Khashab Maria A. Aronova Guangming Lu Xiaoyuan Chen
author_sort	Wenpei Fan
title	Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy
title_short	Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy
title_full	Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy
title_fullStr	Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy
title_full_unstemmed	Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy
title_sort	generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent x-ray-activated synergistic therapy
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-03-01
description	A common failure of many cancer treatments is attributed to the resistance imparted by tumour hypoxia. Here, the authors report on the generic synthesis of small-sized hollow mesoporous organosilica nanoparticles which are designed for oxygen-independent X-ray-activated synergistic therapy.
url	https://doi.org/10.1038/s41467-019-09158-1
work_keys_str_mv	AT wenpeifan genericsynthesisofsmallsizedhollowmesoporousorganosilicananoparticlesforoxygenindependentxrayactivatedsynergistictherapy AT nanlu genericsynthesisofsmallsizedhollowmesoporousorganosilicananoparticlesforoxygenindependentxrayactivatedsynergistictherapy AT zheyushen genericsynthesisofsmallsizedhollowmesoporousorganosilicananoparticlesforoxygenindependentxrayactivatedsynergistictherapy AT weitang genericsynthesisofsmallsizedhollowmesoporousorganosilicananoparticlesforoxygenindependentxrayactivatedsynergistictherapy AT boshen genericsynthesisofsmallsizedhollowmesoporousorganosilicananoparticlesforoxygenindependentxrayactivatedsynergistictherapy AT zhaowencui genericsynthesisofsmallsizedhollowmesoporousorganosilicananoparticlesforoxygenindependentxrayactivatedsynergistictherapy AT linglingshan genericsynthesisofsmallsizedhollowmesoporousorganosilicananoparticlesforoxygenindependentxrayactivatedsynergistictherapy AT zhenyang genericsynthesisofsmallsizedhollowmesoporousorganosilicananoparticlesforoxygenindependentxrayactivatedsynergistictherapy AT zhantongwang genericsynthesisofsmallsizedhollowmesoporousorganosilicananoparticlesforoxygenindependentxrayactivatedsynergistictherapy AT oritjacobson genericsynthesisofsmallsizedhollowmesoporousorganosilicananoparticlesforoxygenindependentxrayactivatedsynergistictherapy AT zijianzhou genericsynthesisofsmallsizedhollowmesoporousorganosilicananoparticlesforoxygenindependentxrayactivatedsynergistictherapy AT yijingliu genericsynthesisofsmallsizedhollowmesoporousorganosilicananoparticlesforoxygenindependentxrayactivatedsynergistictherapy AT pinghu genericsynthesisofsmallsizedhollowmesoporousorganosilicananoparticlesforoxygenindependentxrayactivatedsynergistictherapy AT weijingyang genericsynthesisofsmallsizedhollowmesoporousorganosilicananoparticlesforoxygenindependentxrayactivatedsynergistictherapy AT jibinsong genericsynthesisofsmallsizedhollowmesoporousorganosilicananoparticlesforoxygenindependentxrayactivatedsynergistictherapy AT yangzhang genericsynthesisofsmallsizedhollowmesoporousorganosilicananoparticlesforoxygenindependentxrayactivatedsynergistictherapy AT liwenzhang genericsynthesisofsmallsizedhollowmesoporousorganosilicananoparticlesforoxygenindependentxrayactivatedsynergistictherapy AT niveenmkhashab genericsynthesisofsmallsizedhollowmesoporousorganosilicananoparticlesforoxygenindependentxrayactivatedsynergistictherapy AT mariaaaronova genericsynthesisofsmallsizedhollowmesoporousorganosilicananoparticlesforoxygenindependentxrayactivatedsynergistictherapy AT guangminglu genericsynthesisofsmallsizedhollowmesoporousorganosilicananoparticlesforoxygenindependentxrayactivatedsynergistictherapy AT xiaoyuanchen genericsynthesisofsmallsizedhollowmesoporousorganosilicananoparticlesforoxygenindependentxrayactivatedsynergistictherapy
_version_	1721445398410690560

Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy

Similar Items