Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy
A common failure of many cancer treatments is attributed to the resistance imparted by tumour hypoxia. Here, the authors report on the generic synthesis of small-sized hollow mesoporous organosilica nanoparticles which are designed for oxygen-independent X-ray-activated synergistic therapy.
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2019-03-01
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Online Access: | https://doi.org/10.1038/s41467-019-09158-1 |
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doaj-a33428d6ae6947ed8bb47a3b9835cc6e2021-05-11T12:06:58ZengNature Publishing GroupNature Communications2041-17232019-03-0110111410.1038/s41467-019-09158-1Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapyWenpei Fan0Nan Lu1Zheyu Shen2Wei Tang3Bo Shen4Zhaowen Cui5Lingling Shan6Zhen Yang7Zhantong Wang8Orit Jacobson9Zijian Zhou10Yijing Liu11Ping Hu12Weijing Yang13Jibin Song14Yang Zhang15Liwen Zhang16Niveen M. Khashab17Maria A. Aronova18Guangming Lu19Xiaoyuan Chen20Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthDepartment of Radiology, the Second Affiliated Hospital, Zhejiang University School of MedicineLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthInstitute of Radiation Medicine, Fudan UniversityState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of SciencesLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of SciencesLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthSmart Hybrid Materials Laboratory (SHMs), Advanced Membranes and Porous Materials Center, King Abdullah University of Science and TechnologySmart Hybrid Materials Laboratory (SHMs), Advanced Membranes and Porous Materials Center, King Abdullah University of Science and TechnologySmart Hybrid Materials Laboratory (SHMs), Advanced Membranes and Porous Materials Center, King Abdullah University of Science and TechnologyLaboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthDepartment of Medical Imaging, Jinling Hospital, Medical School of Nanjing UniversityLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthA common failure of many cancer treatments is attributed to the resistance imparted by tumour hypoxia. Here, the authors report on the generic synthesis of small-sized hollow mesoporous organosilica nanoparticles which are designed for oxygen-independent X-ray-activated synergistic therapy.https://doi.org/10.1038/s41467-019-09158-1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wenpei Fan Nan Lu Zheyu Shen Wei Tang Bo Shen Zhaowen Cui Lingling Shan Zhen Yang Zhantong Wang Orit Jacobson Zijian Zhou Yijing Liu Ping Hu Weijing Yang Jibin Song Yang Zhang Liwen Zhang Niveen M. Khashab Maria A. Aronova Guangming Lu Xiaoyuan Chen |
spellingShingle |
Wenpei Fan Nan Lu Zheyu Shen Wei Tang Bo Shen Zhaowen Cui Lingling Shan Zhen Yang Zhantong Wang Orit Jacobson Zijian Zhou Yijing Liu Ping Hu Weijing Yang Jibin Song Yang Zhang Liwen Zhang Niveen M. Khashab Maria A. Aronova Guangming Lu Xiaoyuan Chen Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy Nature Communications |
author_facet |
Wenpei Fan Nan Lu Zheyu Shen Wei Tang Bo Shen Zhaowen Cui Lingling Shan Zhen Yang Zhantong Wang Orit Jacobson Zijian Zhou Yijing Liu Ping Hu Weijing Yang Jibin Song Yang Zhang Liwen Zhang Niveen M. Khashab Maria A. Aronova Guangming Lu Xiaoyuan Chen |
author_sort |
Wenpei Fan |
title |
Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy |
title_short |
Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy |
title_full |
Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy |
title_fullStr |
Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy |
title_full_unstemmed |
Generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy |
title_sort |
generic synthesis of small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent x-ray-activated synergistic therapy |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2019-03-01 |
description |
A common failure of many cancer treatments is attributed to the resistance imparted by tumour hypoxia. Here, the authors report on the generic synthesis of small-sized hollow mesoporous organosilica nanoparticles which are designed for oxygen-independent X-ray-activated synergistic therapy. |
url |
https://doi.org/10.1038/s41467-019-09158-1 |
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