Expression of HER2/neu and Ki-67 in Urothelial Carcinoma and their Relation to Clinicopathological Data: An Egyptian Study
Introduction: Bladder cancer is the most common malignancy involving the urinary system and the ninth most common malignancy worldwide. Ki-67 is a nonhistone cellular marker for proliferation. HER2/neu is an oncogene that plays an important role in the pathogenesis of many cancer types. In bladd...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2021-03-01
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Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://jcdr.net/articles/PDF/14624/45922_CE[Ra]_F(Sh)_PF1(ShG_KM)_PFA(SHU_ShG_KM)_PN(SHU).pdf |
Summary: | Introduction: Bladder cancer is the most common malignancy
involving the urinary system and the ninth most common
malignancy worldwide. Ki-67 is a nonhistone cellular marker for
proliferation. HER2/neu is an oncogene that plays an important
role in the pathogenesis of many cancer types. In bladder
carcinoma, its clinical significance remains under-investigated
and poorly linked to the patients’ clinicopathological features
especially with no reported Egyptian study.
Aim: The aim of this work was to study the expression of HER2/
neu and Ki-67 in urinary bladder carcinoma to evaluate their
role in tumourigenesis and their correlation with other available
clinicopathological variables associated with urothelial carcinoma.
Materials and Methods: This cross-sectional study was
conducted at the Department of Pathology, Faculty of Medicine,
Cairo University, Egypt. Samples were paraffin blocks from 60
cases diagnosed with urothelial carcinoma underwent radical
cystectomy. Ki-67 and HER2/neu immunohistochemical
staining was done and of Ki-67 and HER2/neu Immunostaining
was recorded. The associations between Ki-67, HER2/neu
expressions and clinical and histopathological parameters of
urothelial bladder carcinoma was evaluated.
Results: The Ki-67 expression had significant association with
tumour histological grade and lymphovascular invasion (p-value
<0.05). The association of HER2/neu expression had significant
association with perineural invasion (p-value <0.05).
Conclusion: HER2/neu immunostaining was not associated
with most of the clinicopathologic prognostic factors in urothelial
bladder carcinoma. |
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ISSN: | 2249-782X 0973-709X |