Combined therapeutic effects of HIFU, GnRH-a and LNG-IUS for the treatment of severe adenomyosis
Objective: To evaluate the combined efficacy of high-intensity focused ultrasound (HIFU), gonadotropin-releasing hormone agonist (GnRH-a) and the levonorgestrel-releasing intrauterine system (LNG-IUS) for the treatment of severe adenomyosis. Method: Four hundred and sixty-six patients with adenomyos...
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Online Access: | http://dx.doi.org/10.1080/02656736.2019.1595179 |
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doaj-a344fac857074c328863e85d230f0e652020-11-25T02:53:06ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572019-01-0136148549110.1080/02656736.2019.15951791595179Combined therapeutic effects of HIFU, GnRH-a and LNG-IUS for the treatment of severe adenomyosisXinhua Yang0Xiaofei Zhang1Bin Lin2Xiao Feng3Aixingzi Aili4Tongji University School of MedicineTongji University School of MedicineTongji University School of MedicineTongji University School of MedicineTongji University School of MedicineObjective: To evaluate the combined efficacy of high-intensity focused ultrasound (HIFU), gonadotropin-releasing hormone agonist (GnRH-a) and the levonorgestrel-releasing intrauterine system (LNG-IUS) for the treatment of severe adenomyosis. Method: Four hundred and sixty-six patients with adenomyosis admitted to the Department of Gynecology of Shanghai First Maternity and Infant Hospital underwent HIFU treatment, and then were consecutively administered with GnRH-a 1 d, 1 month and 3 months after HIFU treatment. The uterine size was then measured with ultrasound or MRI 2–4 weeks after three cycles of GnRH-a injection. The LNG-IUS was then inserted when the uterine length less than 9 cm. The visual analog scale (VAS), verbal rating scale (VRS), menstrual volume score, uterus volume, MRI, serum levels of hemoglobin and CA125 were measured at pre and 3-, 6-, 12-month post-HIFU. Results: Dysmenorrhea and menorrhagia significantly relieved after combined treatment with HIFU, GnRH-a and the LNS-IUS. The uterine volume shrank and returned to its normal size. The serum CA-125 level was reduced to the normal level after the combined treatment. Conclusions: The combined therapeutic regimen of HIFU, GnRH-a and LNS-IUS is safe, effective and efficient for curing severe adenomyosis.http://dx.doi.org/10.1080/02656736.2019.1595179high-intensity focused ultrasoundgonadotropin-releasing hormone agonistlevonorgestrel intrauterine deviceadenomyosiscombined therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xinhua Yang Xiaofei Zhang Bin Lin Xiao Feng Aixingzi Aili |
spellingShingle |
Xinhua Yang Xiaofei Zhang Bin Lin Xiao Feng Aixingzi Aili Combined therapeutic effects of HIFU, GnRH-a and LNG-IUS for the treatment of severe adenomyosis International Journal of Hyperthermia high-intensity focused ultrasound gonadotropin-releasing hormone agonist levonorgestrel intrauterine device adenomyosis combined therapy |
author_facet |
Xinhua Yang Xiaofei Zhang Bin Lin Xiao Feng Aixingzi Aili |
author_sort |
Xinhua Yang |
title |
Combined therapeutic effects of HIFU, GnRH-a and LNG-IUS for the treatment of severe adenomyosis |
title_short |
Combined therapeutic effects of HIFU, GnRH-a and LNG-IUS for the treatment of severe adenomyosis |
title_full |
Combined therapeutic effects of HIFU, GnRH-a and LNG-IUS for the treatment of severe adenomyosis |
title_fullStr |
Combined therapeutic effects of HIFU, GnRH-a and LNG-IUS for the treatment of severe adenomyosis |
title_full_unstemmed |
Combined therapeutic effects of HIFU, GnRH-a and LNG-IUS for the treatment of severe adenomyosis |
title_sort |
combined therapeutic effects of hifu, gnrh-a and lng-ius for the treatment of severe adenomyosis |
publisher |
Taylor & Francis Group |
series |
International Journal of Hyperthermia |
issn |
0265-6736 1464-5157 |
publishDate |
2019-01-01 |
description |
Objective: To evaluate the combined efficacy of high-intensity focused ultrasound (HIFU), gonadotropin-releasing hormone agonist (GnRH-a) and the levonorgestrel-releasing intrauterine system (LNG-IUS) for the treatment of severe adenomyosis. Method: Four hundred and sixty-six patients with adenomyosis admitted to the Department of Gynecology of Shanghai First Maternity and Infant Hospital underwent HIFU treatment, and then were consecutively administered with GnRH-a 1 d, 1 month and 3 months after HIFU treatment. The uterine size was then measured with ultrasound or MRI 2–4 weeks after three cycles of GnRH-a injection. The LNG-IUS was then inserted when the uterine length less than 9 cm. The visual analog scale (VAS), verbal rating scale (VRS), menstrual volume score, uterus volume, MRI, serum levels of hemoglobin and CA125 were measured at pre and 3-, 6-, 12-month post-HIFU. Results: Dysmenorrhea and menorrhagia significantly relieved after combined treatment with HIFU, GnRH-a and the LNS-IUS. The uterine volume shrank and returned to its normal size. The serum CA-125 level was reduced to the normal level after the combined treatment. Conclusions: The combined therapeutic regimen of HIFU, GnRH-a and LNS-IUS is safe, effective and efficient for curing severe adenomyosis. |
topic |
high-intensity focused ultrasound gonadotropin-releasing hormone agonist levonorgestrel intrauterine device adenomyosis combined therapy |
url |
http://dx.doi.org/10.1080/02656736.2019.1595179 |
work_keys_str_mv |
AT xinhuayang combinedtherapeuticeffectsofhifugnrhaandlngiusforthetreatmentofsevereadenomyosis AT xiaofeizhang combinedtherapeuticeffectsofhifugnrhaandlngiusforthetreatmentofsevereadenomyosis AT binlin combinedtherapeuticeffectsofhifugnrhaandlngiusforthetreatmentofsevereadenomyosis AT xiaofeng combinedtherapeuticeffectsofhifugnrhaandlngiusforthetreatmentofsevereadenomyosis AT aixingziaili combinedtherapeuticeffectsofhifugnrhaandlngiusforthetreatmentofsevereadenomyosis |
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