Hepatosplenic T Cell Lymphoma in an Immunocompetent Female Diagnosed using Flow Cytometry: A Rare Clinical Entity

• Main Authors: Pranav Dorwal, Ritesh Sachdev, Amit Pande, Dharmendra Jain, Bhawna Jha, Vimarsh Raina
• Format: Article
• Language: English
• Published: JCDR Research and Publications Private Limited 2016-08-01
• Series: Journal of Clinical and Diagnostic Research
• Subjects: immunophenotyping; cluster of differentiation; hepatosplenomegaly; pancytopenia
• Online Access: https://jcdr.net/articles/PDF/8355/16943_CE[Ra]_F(P)_PF1(ROAK)_PFA(AK)_PF2(PRAK)_PFA2(AK).pdf

Hepatosplenic T-cell lymphoma is a rare haematopoietic malignancy that comprises less than 1% of Non-Hodgkin lymphomas. We are reporting a case of a 26-year-old female, who presented with pallor, weight loss, jaundice, pancytopenia and hepatosplenomegaly. The bone marrow examination showed infiltration by lymphoid cells. These cells on flow cytometric evaluation showed the phenotype of hepatosplenic T cell lymphoma. The cells were positive for CD3, CD8, CD56 and TCR γδ and negative for CD5, CD4, CD8, CD16, CD57, TCRαβ along with B cell markers. This case is reported for being a rare clinical entity and its presence in an immunocompetent female making it rarer.